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Updated: Aug 1, 2025

Author Spotlight: Evaluating the Adjuvant Efficacy and Safety of Angong Niuhuang Pill in Viral Encephalitis Treatment
Published on: April 19, 2024
Risk factors of epilepsy secondary to viral encephalitis: A meta-analysis
1Department of Neurology, The first affiliated Hospital of Chengdu Medical College, Chengdu 610500, China.
Objective:
To systematically evaluate the risk factors of post-encephalitis epilepsy (PEE).
Methods:
Systematic computerized searches of databases such as Cochrane Library, PubMed and EMBASE were performed. The meta-analysis of pooled odds ratios and 95% confidence intervals for PEE risk were calculated.
Results:
Sixteen studies with 2504 patients were included for meta-analysis. The results showed that PEE was associated with coma, seizure, status epilepticus, cranial MRI abnormality, focal EEG abnormality, and positive herpes simplex virus (HSV) in cerebrospinal fluid (CSF).
Conclusion:
Coma, seizures or status epilepticus, abnormal MRI and focal EEG, and HSV in CSF were the risk factors of PEE.
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