Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Biological Causes of Schizophrenia01:29

Biological Causes of Schizophrenia

108
Schizophrenia, a severe psychiatric disorder, arises from a complex interplay of biological factors, including genetic predisposition, structural brain abnormalities, neurotransmitter dysregulation, and developmental irregularities. These factors collectively contribute to the onset and progression of the disorder, which typically manifests in late adolescence or early adulthood.
Genetic Factors in Schizophrenia
The genetic basis of schizophrenia is strongly supported by family and twin...
108
Depressive Disorders: Etiology01:27

Depressive Disorders: Etiology

147
Depressive disorders result from a complex interplay of biological, psychological, and sociocultural factors, each contributing uniquely to the development and persistence of the condition. Understanding these factors provides critical insight into the multifaceted nature of depression.
Biological Factors in Depression
Biological predispositions significantly influence the risk of developing depressive disorders. Genetic studies highlight the role of variations in the serotonin transporter...
147
Psychosis: Pathophysiology of Schizophrenia and Other Psychotic Disorders01:27

Psychosis: Pathophysiology of Schizophrenia and Other Psychotic Disorders

787
Schizophrenia is a neurodevelopmental disorder whose origins are rooted in complex genetic components. Despite our burgeoning understanding, the pathophysiology of this disorder remains incompletely deciphered.
Researchers have identified genetic factors that increase susceptibility to schizophrenia, underscoring the intricate interplay between genetics and environment in disease development. At the core of schizophrenia's pathophysiology is excessive dopaminergic neurotransmission within...
787
Introduction to Biological Bases of Psychology01:30

Introduction to Biological Bases of Psychology

3.3K
Biopsychology serves as a vital bridge connecting the intricate domains of biology and psychology, shedding light on how biological systems influence psychological phenomena. This field scrutinizes the biological substrates of behavior and mental processes, emphasizing the nervous system along with the roles of neurotransmitters, hormones, and genetics. It also incorporates evolutionary perspectives to explain the adaptive nature of mental functions.
The nervous system, the cornerstone of...
3.3K
Theoretical Approaches to Psychological Disorder01:29

Theoretical Approaches to Psychological Disorder

266
The development of psychological disorders, which are characterized by deviant, maladaptive, and personally distressing behaviors, has been explored through several theoretical approaches.
Biological approach
The biological approach posits that internal, organic factors are the primary causes of such disorders. This perspective emphasizes brain structure and function, genetic predispositions, and neurotransmitter imbalances. For example, schizophrenia has been associated with both genetic...
266
Psychological and Sociocultural Causes of Schizophrenia01:29

Psychological and Sociocultural Causes of Schizophrenia

151
Schizophrenia, a complex psychiatric disorder, has been historically misunderstood. Early psychological theories attributed its origins to childhood trauma and unresponsive parenting. However, contemporary research largely rejects these notions, favoring the vulnerability-stress hypothesis. This model proposes that individuals with a genetic predisposition to schizophrenia may develop the disorder following exposure to significant environmental stressors. Notably, studies on high-risk...
151

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

A longitudinal DNA methylation atlas and its link to brain structure and mental health.

Molecular psychiatry·2026
Same author

From chronic pain to depression: Neurogenesis-driven microglial remodeling in the hippocampal dentate gyrus.

Science (New York, N.Y.)·2026
Same author

Neurocognitive characterization of behaviour and mental illness through time-varying brain network analysis.

Nature communications·2026
Same author

Downregulation of integrin α3 in ADHD mirrored in mutant mouse model by dopamine-dependent hippocampal AMPAR expression.

Molecular psychiatry·2025
Same author

A psychobiological resilience factor for mental health across the lifespan.

Research square·2025
Same author

Neural correlates of reduced sensitivity to information about uncertainty during valuation in older adults: An fNIRS study.

Imaging neuroscience (Cambridge, Mass.)·2025
Same journal

Author Correction: Teclistamab-based induction treatment in transplant-eligible, newly diagnosed multiple myeloma: a phase 2 trial.

Nature medicine·2026
Same journal

Data rights are the missing pillar for modernizing consent in medicine.

Nature medicine·2026
Same journal

Generalizable AI predicts immunotherapy outcomes across cancers and treatments.

Nature medicine·2026
Same journal

Immune aging biomarkers for clinical trials.

Nature medicine·2026
Same journal

Lassa fever countermeasures gather pace.

Nature medicine·2026
Same journal

Why high scores do not mean application readiness for health AI.

Nature medicine·2026
See all related articles

Related Experiment Video

Updated: Aug 1, 2025

A New Method for Inducing a Depression-Like Behavior in Rats
07:57

A New Method for Inducing a Depression-Like Behavior in Rats

Published on: February 22, 2018

21.0K

A shared neural basis underlying psychiatric comorbidity.

Chao Xie1,2, Shitong Xiang1,2, Chun Shen1,2

  • 1Institute of Science and Technology for Brain-Inspired Intelligence, Fudan University, Shanghai, China.

Nature Medicine
|April 24, 2023
PubMed
Summary
This summary is machine-generated.

Researchers identified a unified neuropsychopathological (NP) factor linking psychiatric disorders. This factor, linked to delayed prefrontal cortex development and poor executive function, offers a potential target for new mental health interventions.

More Related Videos

Developing Neuroimaging Phenotypes of the Default Mode Network in PTSD: Integrating the Resting State, Working Memory, and Structural Connectivity
10:43

Developing Neuroimaging Phenotypes of the Default Mode Network in PTSD: Integrating the Resting State, Working Memory, and Structural Connectivity

Published on: July 1, 2014

15.2K
Exploring the Neural Correlates of Cognitive Reappraisal in Obsessive-Compulsive Disorder Using Task-based Functional Magnetic Resonance Imaging
09:14

Exploring the Neural Correlates of Cognitive Reappraisal in Obsessive-Compulsive Disorder Using Task-based Functional Magnetic Resonance Imaging

Published on: March 14, 2025

274

Related Experiment Videos

Last Updated: Aug 1, 2025

A New Method for Inducing a Depression-Like Behavior in Rats
07:57

A New Method for Inducing a Depression-Like Behavior in Rats

Published on: February 22, 2018

21.0K
Developing Neuroimaging Phenotypes of the Default Mode Network in PTSD: Integrating the Resting State, Working Memory, and Structural Connectivity
10:43

Developing Neuroimaging Phenotypes of the Default Mode Network in PTSD: Integrating the Resting State, Working Memory, and Structural Connectivity

Published on: July 1, 2014

15.2K
Exploring the Neural Correlates of Cognitive Reappraisal in Obsessive-Compulsive Disorder Using Task-based Functional Magnetic Resonance Imaging
09:14

Exploring the Neural Correlates of Cognitive Reappraisal in Obsessive-Compulsive Disorder Using Task-based Functional Magnetic Resonance Imaging

Published on: March 14, 2025

274

Area of Science:

  • Neuroscience
  • Psychiatry
  • Genetics

Background:

  • Common comorbidities exist among psychiatric disorders, suggesting an underlying general psychopathology factor.
  • Neurobiological mechanisms and generalizability of this factor remain unclear.

Purpose of the Study:

  • To define a neuropsychopathological (NP) factor across externalizing and internalizing symptoms.
  • To investigate the neurobiological underpinnings and generalizability of the NP factor.

Main Methods:

  • Utilized a large longitudinal neuroimaging cohort (IMAGEN) from adolescence to young adulthood.
  • Employed multitask connectomes to define the NP factor.
  • Validated findings in multiple developmental periods and clinical samples (ADHD-200, Stratify Project).

Main Results:

  • The NP factor represents a unified, genetically determined, delayed development of the prefrontal cortex.
  • This NP factor is associated with poor executive function.
  • The NP factor demonstrated reproducibility across developmental stages and generalizability to resting-state connectomes and clinical populations.

Conclusions:

  • Identified a reproducible and general neural basis for psychiatric disorder comorbidities.
  • Bridged behavioral, neuroimaging, and genetic evidence for a unified NP factor.
  • Findings may inform novel therapeutic interventions for psychiatric comorbidities.