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Updated: Aug 1, 2025
09:29
Early Viral Entry Assays for the Identification and Evaluation of Antiviral Compounds
Published on: October 29, 2015
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Emerging drugs for hepatitis D.
Onur Keskin1, Cihan Yurdaydin2
1Department of Gastroenterology, Hacettepe University, Ankara, Turkey.
Expert Opinion on Emerging Drugs
|April 25, 2023
Summary
New treatments for chronic hepatitis delta (CHD) show promise. Bulevirtide, lonafarnib, nucleic acid polymers, and pegIFN lambda offer improved antiviral efficacy and safety profiles for managing this severe liver disease.
Area of Science:
- Hepatology
- Virology
- Pharmacology
Background:
- Chronic hepatitis delta (CHD) is the most severe form of chronic viral hepatitis.
- Historically, treatment relied on pegylated interferon alfa (pegIFN).
Purpose of the Study:
- To review current and emerging therapeutic agents for CHD.
- To evaluate the efficacy and safety of novel CHD treatments.
Main Methods:
- Review of clinical trial data for bulevirtide, lonafarnib, nucleic acid polymers, and pegIFN lambda.
- Analysis of antiviral efficacy, safety profiles, and combination therapy potential.
Main Results:
- Bulevirtide demonstrates safety and increasing efficacy with duration; combination with pegIFN shows short-term high efficacy.
- Lonafarnib inhibits viral assembly, with improved efficacy when combined with ritonavir and pegIFN; associated with GI toxicity.
- Nucleic acid polymers achieved HBsAg clearance in a significant patient proportion.
- PegIFN lambda shows fewer side effects than traditional pegIFN, with sustained viral response in one-third of patients post-treatment.
Conclusions:
- Novel agents like bulevirtide, lonafarnib, nucleic acid polymers, and pegIFN lambda represent significant advancements in CHD treatment.
- Combination therapies and agents with improved safety profiles offer new hope for managing severe viral hepatitis.
Keywords:
Chronic hepatitis deltabulevirtide, lonafarnibnucleic acid polymerspegylated interferon alfapegylated interferon lambdatreatmentMore Related Videos
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