Related Experiment Video
Updated: Aug 1, 2025
Testing Cancer Immunotherapeutics in a Humanized Mouse Model Bearing Human Tumors
Published on: December 16, 2022
Establishment of humanized mice and its application progress in cancer immunotherapy
Tianlong Ding1,2, Yang Yu1, Xiaoyuan Pan3
1The Second Clinical Medical College, Lanzhou University, Lanzhou, 730030, PR China.
Abstract:
The current high prevalence of malignant tumors has attracted considerable attention, and treating advanced malignancies is becoming increasingly difficult. Although immunotherapy is a hopeful alternative, it is effective in only a few people. Thus, development of preclinical animal models is needed. Humanized xenotransplantation mouse models can help with selecting treatment protocols, evaluating curative effects and assessing prognosis. This review discusses the establishment of humanized mouse models and their application prospects in cancer immunotherapy to identify tailored therapies for individual patients.
Insights
Developing humanized mouse models is crucial for advancing cancer immunotherapy. These preclinical models aid in personalizing cancer treatments and improving patient outcomes.
Area of Science:
- Oncology
- Immunology
- Preclinical Research
Background:
- Malignant tumors are highly prevalent, posing significant treatment challenges.
- Current cancer immunotherapies show limited efficacy in many patients.
- There is a critical need for effective preclinical models in cancer research.
Purpose of the Study:
- To review the establishment of humanized mouse models.
- To explore the application of these models in cancer immunotherapy.
- To identify strategies for developing tailored cancer therapies.
Main Methods:
- Discussion of humanized xenotransplantation mouse model creation.
- Review of current literature on model applications in immunotherapy.
- Analysis of model utility in treatment selection and prognosis assessment.
Main Results:
- Humanized mouse models offer a platform for evaluating cancer treatments.
- These models facilitate the assessment of immunotherapy efficacy.
- They aid in predicting patient prognosis and treatment response.
Conclusions:
- Humanized mouse models are essential for advancing cancer immunotherapy research.
- These models hold promise for identifying personalized treatment strategies.
- Further development and application of these models can improve patient care for advanced malignancies.
