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Gene Expression Profiling of Infecting Microbes Using a Digital Bar-coding Platform

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High-Throughput Profiling of Candida auris Isolates Reveals Clade-Specific Metabolic Differences.

Philipp Brandt¹, Mohammad H Mirhakkak², Lysett Wagner¹

¹Septomics Research Center, Friedrich Schiller University, and Leibniz Institute for Natural Product Research and Infection Biology, Hans Knöll Institute, Jena, Germany.

Microbiology Spectrum

|April 25, 2023

Summary

This study reveals unique metabolic capabilities in Candida auris, a multidrug-resistant fungus. These metabolic differences across its clades may explain its emergence as a significant human pathogen.

Keywords:

Candida auris Jen2 carboxylic acids dicarboxylic acids dipeptide transport dipeptides metabolism phenotypic profiling

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Area of Science:

Medical Mycology
Fungal Pathogenesis
Antimicrobial Resistance

Background:

Candida auris is an emerging multidrug-resistant fungal pathogen causing invasive infections, with four distinct clades identified.
Previous research suggested metabolic differences contribute to C. auris emergence, but comprehensive clade-specific metabolic characterization was lacking.

Conclusions:

Candida auris exhibits unique metabolic features, including specific nutrient utilization and gene expression patterns, which likely contribute to its emergence and pathogenicity.
The identified clade- and strain-specific metabolic phenotypes provide crucial data for understanding the role of metabolism in the rise of this multidrug-resistant fungus.