Related Experiment Video
Updated: Aug 1, 2025
09:13
Gene Expression Profiling of Infecting Microbes Using a Digital Bar-coding Platform
Published on: January 13, 2016
8.1K
High-Throughput Profiling of Candida auris Isolates Reveals Clade-Specific Metabolic Differences
Philipp Brandt1, Mohammad H Mirhakkak2, Lysett Wagner1
1Septomics Research Center, Friedrich Schiller University, and Leibniz Institute for Natural Product Research and Infection Biology, Hans Knöll Institute, Jena, Germany.
Microbiology Spectrum
|April 25, 2023
Summary
This study reveals unique metabolic capabilities in Candida auris, a multidrug-resistant fungus. These metabolic differences across its clades may explain its emergence as a significant human pathogen.
Area of Science:
- Medical Mycology
- Fungal Pathogenesis
- Antimicrobial Resistance
Background:
- Candida auris is an emerging multidrug-resistant fungal pathogen causing invasive infections, with four distinct clades identified.
- Previous research suggested metabolic differences contribute to C. auris emergence, but comprehensive clade-specific metabolic characterization was lacking.
Conclusions:
- Candida auris exhibits unique metabolic features, including specific nutrient utilization and gene expression patterns, which likely contribute to its emergence and pathogenicity.
- The identified clade- and strain-specific metabolic phenotypes provide crucial data for understanding the role of metabolism in the rise of this multidrug-resistant fungus.
