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Updated: Aug 1, 2025

Vessel-sparing Excision and Primary Anastomosis
Published on: January 7, 2019
History of endoscopic treatment of vesicoureteral reflux
1Department of Paediatric Urology, Karolinska University Hospital, Solna, 17176, Stockholm, Sweden. balazs.kutasy@regionstockholm.se.
Insights
Endoscopic subureteral injection is a popular, safe, and effective minimally invasive treatment for vesicoureteral reflux (VUR) in children, offering an alternative to antibiotics and surgery.
Area of Science:
- Pediatric Urology
- Minimally Invasive Surgery
- Medical Device Technology
Background:
- Vesicoureteral reflux (VUR) in children traditionally managed with antibiotics or surgery.
- Endoscopic subureteral injection emerged as a less invasive alternative in 1984.
- Growing popularity and adoption of the endoscopic procedure worldwide.
Purpose of the Study:
- To review the historical development and evolution of endoscopic treatment for VUR in children.
- To highlight the increasing significance of minimally invasive techniques in pediatric urology.
Main Methods:
- Review of historical data and clinical applications of endoscopic subureteral injection for VUR.
- Analysis of safety and long-term efficacy studies.
- Examination of treatment trends in pediatric VUR management.
Main Results:
- Endoscopic subureteral injection is a safe and effective day-care procedure.
- Demonstrated long-term efficacy, leading to widespread adoption.
- Accounts for nearly 90% of VUR surgical treatments in Sweden.
Conclusions:
- Endoscopic subureteral injection has become a primary treatment modality for pediatric VUR.
- Minimally invasive outpatient procedures offer significant advantages over traditional methods.
- The technique's development reflects advancements in pediatric urological interventions.
Abstract:
Since its first clinical application in 1984, the endoscopic subureteral injection of bulking agents has become an alternative to long-term antibiotic prophylaxis and open surgical intervention in the treatment of VUR in children. The 15 min day care endoscopic procedure has gained worldwide popularity in the management of VUR in children. Over the years, multiple studies have demonstrated safety and long-term efficacy of this minimally invasive outpatient procedure. Nowadays almost 90% of the surgical treatment of VUR in Sweden is done by endoscopic procedure. In the current article, our aim was to review how the endoscopic treatment of VUR developed.
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