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New long-acting 3-azinomethyl-rifamycins
Il Farmaco; Edizione Scientifica
|March 1, 1986
Abstract:
A number of basic 3-azinomethyl-rifamycins have been prepared. Their synthesis and antibacterial activity in vitro are reported, as well as the preliminary pharmacokinetic data. While the antimicrobial activity is comparable with that of rifampicin, serum levels in mice are much longer lasting. One of the compounds was selected for further studies.