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Updated: Aug 1, 2025

Quantifying Cytoskeleton Dynamics Using Differential Dynamic Microscopy
Published on: June 15, 2022
Information-theoretical analysis of statistical measures for multiscale dynamics
Naoki Asuke1, Tomoki Yamagami1, Takatomo Mihana1
1Department of Information Physics and Computing, Graduate School of Information Science and Technology, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8656, Japan.
Abstract:
Multiscale entropy (MSE) has been widely used to examine nonlinear systems involving multiple time scales, such as biological and economic systems. Conversely, Allan variance has been used to evaluate the stability of oscillators, such as clocks and lasers, ranging from short to long time scales. Although these two statistical measures were developed independently for different purposes in different fields, their interest lies in examining the multiscale temporal structures of physical phenomena under study. We demonstrate that from an information-theoretical perspective, they share some foundations and exhibit similar tendencies. We experimentally confirmed that similar properties of the MSE and Allan variance can be observed in low-frequency fluctuations (LFF) in chaotic lasers and physiological heartbeat data. Furthermore, we calculated the condition under which this consistency between the MSE and Allan variance exists, which is related to certain conditional probabilities. Heuristically, natural physical systems including the aforementioned LFF and heartbeat data mostly satisfy this condition, and hence, the MSE and Allan variance demonstrate similar properties. As a counterexample, we demonstrate an artificially constructed random sequence, for which the MSE and Allan variance exhibit different trends.
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