Jove
Visualize
Contact Us

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

A merged lattice metal nanohole array based dual-mode plasmonic laser with an ultra-low threshold.

Nanoscale advancesยท2022
See all related articles
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Video

Updated: Aug 1, 2025

Author Spotlight: Development and Application of SERS Flexible Substrates Using Synthesized AgNPs
03:33

Author Spotlight: Development and Application of SERS Flexible Substrates Using Synthesized AgNPs

Published on: November 17, 2023

2.4K

Graphene surface plasmon sensor for ultra-low-level SARS-CoV-2 detection.

Md Mahbub Hossain1, Muhammad Anisuzzaman Talukder1

  • 1Department of Electrical and Electronic Engineering, Bangladesh University of Engineering and Technology, Dhaka, Bangladesh.

Plos One
|April 25, 2023
PubMed
Summary

A novel graphene-based sensor functionalized with ACE2 antibodies can detect ultra-low concentrations of SARS-CoV-2. This sensitive, portable, and rapid detection method is crucial for managing COVID-19.

More Related Videos

Development and Functionalization of Electrolyte-Gated Graphene Field-Effect Transistor for Biomarker Detection
07:51

Development and Functionalization of Electrolyte-Gated Graphene Field-Effect Transistor for Biomarker Detection

Published on: February 1, 2022

3.3K
Author Spotlight: Tracking Electrochemistry on Single Nanoparticles with Surface-Enhanced Raman Scattering Spectroscopy and Microscopy
10:59

Author Spotlight: Tracking Electrochemistry on Single Nanoparticles with Surface-Enhanced Raman Scattering Spectroscopy and Microscopy

Published on: May 12, 2023

2.8K

Related Experiment Videos

Last Updated: Aug 1, 2025

Author Spotlight: Development and Application of SERS Flexible Substrates Using Synthesized AgNPs
03:33

Author Spotlight: Development and Application of SERS Flexible Substrates Using Synthesized AgNPs

Published on: November 17, 2023

2.4K
Development and Functionalization of Electrolyte-Gated Graphene Field-Effect Transistor for Biomarker Detection
07:51

Development and Functionalization of Electrolyte-Gated Graphene Field-Effect Transistor for Biomarker Detection

Published on: February 1, 2022

3.3K
Author Spotlight: Tracking Electrochemistry on Single Nanoparticles with Surface-Enhanced Raman Scattering Spectroscopy and Microscopy
10:59

Author Spotlight: Tracking Electrochemistry on Single Nanoparticles with Surface-Enhanced Raman Scattering Spectroscopy and Microscopy

Published on: May 12, 2023

2.8K

Area of Science:

  • Nanotechnology
  • Biosensing
  • Materials Science

Background:

  • Accurate detection of SARS-CoV-2 at ultra-low levels is critical for COVID-19 management.
  • Existing detection methods often lack the required sensitivity, portability, speed, or cost-effectiveness.

Purpose of the Study:

  • To propose and analyze a novel sensor for sensitive, low-cost, portable, and rapid detection of SARS-CoV-2.
  • To leverage graphene surface plasmon resonance enhanced by 2D materials for ultra-low concentration detection.

Main Methods:

  • Development of a graphene surface plasmon resonance sensor.
  • Functionalization of the graphene layer with angiotensin-converting enzyme 2 (ACE2) antibodies.
  • Integration of ultra-thin layers of tungsten disulfide (WS2), potassium niobate (KNbO3), and black phosphorus (BP) or blue phosphorus (BlueP) to enhance light absorption.

Main Results:

  • The proposed sensor demonstrated the capability to detect SARS-CoV-2 at concentrations as low as approximately 1 fM.
  • Achieved a minimum sensitivity of 201 degrees/RIU and a figure-of-merit of 140 RIU-1.
  • Observed enhanced binding kinetics of SARS-CoV-2 to the sensor surface.

Conclusions:

  • The developed graphene-based SPR sensor offers a promising solution for ultra-low-level SARS-CoV-2 detection.
  • The sensor's design incorporating novel 2D materials enhances sensitivity and detection limits.
  • This technology has the potential for widespread application in rapid and reliable COVID-19 diagnostics.