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Altered serum bile acid composition is associated with cardiac dysfunction in cirrhosis
Signe Wiese1,2, Karen V Danielsen1, Troels Busk2,3
1Gastro Unit, Medical Division, Hvidovre Hospital, Hvidovre, Denmark.
Elevated conjugated bile acids (BA) in cirrhosis patients are linked to heart abnormalities and hyperdynamic circulation. Taurine-conjugated BA also correlate with portal hypertension, suggesting a role in disease progression.
Area of Science:
- Cardiology
- Hepatology
- Biochemistry
Background:
- Elevated serum bile acids (BA) are implicated in cardiac harm.
- Altered BA composition may cause cardiovascular issues in cirrhosis.
Purpose of the Study:
- To investigate associations between specific serum BA and cardiac abnormalities in cirrhosis patients.
- To explore the link between BA and structural/functional cardiac changes.
Main Methods:
- Explorative study of 86 cirrhosis patients.
- Cardiac MRI with extracellular volume (ECV) quantification for fibrosis.
- Assessed 15 individual serum BA and C4 (de novo BA synthesis marker).
Main Results:
- Cirrhosis patients had higher total and conjugated BA, lower C4.
- Conjugated BA correlated with high cardiac index, increased left atrial volume index (LAVI), and abnormal myocardial ECV.
- Conjugated BA remained associated with LAVI, left ventricular volumes, and cardiac index after adjustment.
Conclusions:
- Increased conjugated BA are linked to cardiac dysfunction and hyperdynamic circulation in cirrhosis.
- Taurine-conjugated BA show association with portal hypertension.
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