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Updated: Aug 1, 2025

Surface Engineering of Pancreatic Islets with a Heparinized StarPEG Nanocoating
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Heparin Prowess: Favorable Vascular-Immune Reprogramming in Pancreatic Cancer

Murray Korc1

  • 1Department of Developmental and Cell Biology, Chao Family Comprehensive Cancer Center, University of California Irvine, Irvine, California.

Clinical Cancer Research : an Official Journal of the American Association for Cancer Research
|April 26, 2023
PubMed

Several approaches for overcoming immunotherapy resistance in pancreatic and colorectal cancer syngeneic models were assessed using heparin and immunotherapy. Beneficial responses were attributed to heparin-induced vascular normalization, ensuing CD8+ T-cell infiltration, and M1 macrophage polarization, suggesting the potential for heparin-anchored therapies in cold tumors such as pancreatic cancer. See related article by Wei et al., p. 2525.

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