Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Peptide derivatives as prodrugs.

W A Thomas

    Biochemical Society Transactions
    |April 1, 1986
    PubMed
    Summary

    Peptide prodrugs offer promising therapeutic potential, enhancing drug delivery and bioavailability. This approach could revolutionize treatments for infections and cancer by targeting specific receptors.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Parturient Apoplexy: A Discussion of "Milk Fever".

    The Journal of comparative medicine and veterinary archives·2022
    Same author

    PATHOLOGY OF CARDIOVASCULAR DISEASE.

    A listing of research in the cardiovascular field·2014
    Same author

    ATHEROSCLEROSIS. LOCAL FACTORS: CONNECTIVE TISSUE REACTIONS.

    A listing of research in the cardiovascular field·2014
    Same author

    Treatment of migraine by intravenous histamine.

    The American journal of medicine·2010
    Same author

    Intravenous administration of histamine in treatment of migraine.

    Archives of neurology and psychiatry·2010
    Same author

    Intravenous histamine in the treatment of migraine.

    Bulletin of the New York Academy of Medicine·2010

    Area of Science:

    • Pharmaceutical Science
    • Medicinal Chemistry
    • Drug Delivery Systems

    Background:

    • Peptides are increasingly explored as versatile platforms for drug development.
    • Modifying drug molecules into peptide prodrugs can overcome limitations in pharmacokinetics and bioavailability.
    • The pharmaceutical industry shows significant interest, evidenced by numerous patent filings.

    Purpose of the Study:

    • To evaluate the therapeutic potential of peptides as prodrugs.
    • To explore the impact of peptide modification on drug pharmacokinetics and bioavailability.
    • To assess the feasibility of using active transport permeases for targeted drug delivery.

    Main Methods:

    • Literature review of studies on peptide prodrugs.
    • Analysis of pharmacokinetic and bioavailability data for modified peptides.
    • Examination of patent landscape in peptide prodrug development.

    Main Results:

    • Peptide prodrugs demonstrate significant positive alterations in pharmacokinetics and bioavailability.
    • Active transport permeases can be utilized for targeted drug delivery to specific receptors.
    • This strategy shows potential for treating bacterial, fungal, viral infections, and cancer.

    Conclusions:

    • Peptide prodrugs represent a viable and promising strategy for future therapeutics.
    • Targeted drug delivery via active transport permeases offers new avenues for disease treatment.
    • The growing patent activity underscores the pharmaceutical industry's commitment to this field.

    Related Experiment Videos