Long non-coding RNAs and gastric cancer: An update of potential biomarkers and therapeutic applications

Area of Science:

• Oncology
• Molecular Biology
• Genetics

Background:

• Gastric cancer (GC) frequently metastasizes, complicating curative treatment and necessitating novel diagnostic and therapeutic strategies.
• Long non-coding RNAs (lncRNAs) are increasingly recognized for their roles in GC, influencing key areas like cancer immunity, metabolism, and metastasis.
• lncRNAs show significant potential as prognostic, diagnostic, and therapeutic agents in GC management.

Purpose of the Study:

• To provide a comprehensive overview of the biological functions of lncRNAs in gastric cancer development.
• To update the current understanding of lncRNA-associated pathological activities, prognostic indicators, and diagnostic tools.
• To review the latest therapeutic strategies targeting lncRNAs for gastric cancer treatment.

Main Methods:

• Literature review of recent studies on lncRNAs in gastric cancer.
• Analysis of lncRNA roles in cancer immunity, metabolism, and metastasis.
• Synthesis of information on prognostic, diagnostic, and therapeutic applications of lncRNAs.

Main Results:

• lncRNAs play multifaceted roles in GC pathogenesis, including modulation of immune responses, metabolic reprogramming, and promotion of metastasis.
• Specific lncRNAs have been identified as valuable biomarkers for predicting patient outcomes and diagnosing GC.
• Emerging therapeutic approaches leverage lncRNAs for targeted treatment of GC, showing promise in preclinical and clinical studies.

Conclusions:

• lncRNAs represent a critical area of research for advancing gastric cancer diagnostics and therapeutics.
• Targeting lncRNAs offers a promising avenue for improving patient prognosis and developing more effective treatments for GC.
• Further investigation into lncRNA mechanisms and clinical applications is essential for optimizing GC management.