Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

In vitro cholesterol gallstone dissolution after fragmentation with shock waves.

M Neubrand, T Sauerbruch, F Stellaard

    Digestion
    |January 1, 1986
    PubMed
    Summary

    Shock wave fragmentation significantly enhances human gallstone dissolution in a bile acid-lecithin solution. Smaller fragments (under 2 mm) dissolve most effectively, suggesting a combined shock wave and bile salt therapy approach.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Interaction of chylomicron remnants and VLDLs during ultracentrifuge separation based on the Svedberg flotation rate.

    Journal of internal medicine·2019
    Same author

    Der Internist·2017
    Same author

    ColoPulse tablets perform comparably in healthy volunteers and Crohn's patients and show no influence of food and time of food intake on bioavailability.

    Journal of controlled release : official journal of the Controlled Release Society·2013
    Same author

    Potential mechanisms explaining why hydrolyzed casein-based diets outclass single amino acid-based diets in the prevention of autoimmune diabetes in diabetes-prone BB rats.

    Diabetes/metabolism research and reviews·2012
    Same author

    Restoration of impaired intestinal barrier function by the hydrolysed casein diet contributes to the prevention of type 1 diabetes in the diabetes-prone BioBreeding rat.

    Diabetologia·2010
    Same author

    Oral ileocolonic drug delivery by the colopulse-system: a bioavailability study in healthy volunteers.

    Journal of controlled release : official journal of the Controlled Release Society·2010

    Area of Science:

    • Gastroenterology
    • Biophysics
    • Biochemistry

    Background:

    • Gallstones are a common ailment, often composed primarily of cholesterol.
    • Current treatments for gallstones have limitations.
    • Understanding factors that enhance gallstone dissolution is crucial for developing effective therapies.

    Purpose of the Study:

    • To investigate the effect of shock wave fragmentation on the dissolution rates of human gallstones.
    • To determine the optimal fragment size for enhanced dissolution.
    • To evaluate the potential of combining shock wave therapy with bile salt solutions.

    Main Methods:

    • In vitro experiments using human gallstones with high cholesterol content.
    • Gallstones were disintegrated using controlled shock wave discharges.

    Related Experiment Videos

  • Dissolution rates were measured in a glycoursodeoxycholic acid (GUDC)-lecithin solution over 10 days.
  • Fragment size analysis and scanning electron microscopy were employed.

    • Main Results:

    • Intact gallstones lost only 4% of cholesterol in 10 days.
    • Shock wave fragmentation increased cholesterol loss to 92% after 300 discharges.
    • Fragments < 2 mm lost 55% cholesterol after 1 day and 99% after 10 days.
    • Large fragments also showed increased dissolution (42% cholesterol loss in 10 days) compared to intact stones.

    Conclusions:

    • Shock wave lithotripsy significantly accelerates cholesterol gallstone dissolution in a GUDC-lecithin solvent.
    • Fragment size is critical, with < 2 mm being most effective.
    • Combined shock wave therapy and bile salt treatment show promise for gallbladder stone management.