Jove
Visualize
Contact Us

Related Experiment Videos

Interaction between 1,2-dichloroethane and disulfiram. I. Toxicologic effects.

O J Igwe, S S Que Hee, W D Wagner

    Fundamental and Applied Toxicology : Official Journal of the Society of Toxicology
    |May 1, 1986
    PubMed
    Summary

    Disulfiram (DSF) exacerbates 1,2-dichloroethane (1,2-DCE) toxicity in rats, causing testicular atrophy and liver damage. This interaction occurs at lower doses than 1,2-DCE alone, highlighting a significant toxicological synergy.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Muscadine Grape Skin Extract in Biochemically Recurrent Prostate Cancer: A Randomized, Placebo-Controlled, Biomarker-Enriched Trial in Patients With the SOD2 Ala/Ala Variant.

    The Prostate·2025
    Same author

    Prooxidant-induced c-Src/nuclear factor kappa B-coupled signalling in sensory ganglia mediates cutaneous hyperalgesia.

    European journal of pain (London, England)·2013
    Same author

    Nanodiamonds in the Younger Dryas boundary sediment layer.

    Science (New York, N.Y.)·2009
    Same author

    Evidence for an extraterrestrial impact 12,900 years ago that contributed to the megafaunal extinctions and the Younger Dryas cooling.

    Proceedings of the National Academy of Sciences of the United States of America·2007
    Same author

    Nitrile glove permeation of benomyl.

    Archives of environmental contamination and toxicology·2006
    Same author

    Agents that act by different mechanisms modulate the activity of protein kinase CbetaII isozyme in the rat spinal cord during peripheral inflammation.

    Neuroscience·2005
    JoVE
    x logofacebook logolinkedin logoyoutube logo
    ABOUT JoVE
    OverviewLeadershipBlogJoVE Help Center
    AUTHORS
    Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
    LIBRARIANS
    TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
    RESEARCH
    JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
    EDUCATION
    JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
    Terms & Conditions of Use
    Privacy Policy
    Policies

    Area of Science:

    • Toxicology
    • Pharmacology
    • Environmental Health

    Background:

    • 1,2-dichloroethane (1,2-DCE) is an industrial chemical with known toxicity.
    • Disulfiram (DSF), used to treat alcoholism, can interact with various substances.
    • Previous studies indicated similar interactions between DSF and ethylene dibromide (EDB).

    Purpose of the Study:

    • To investigate the toxicological interaction between 1,2-DCE and DSF in Sprague-Dawley rats.
    • To determine if DSF modifies the toxicity profile of 1,2-DCE via inhalation or intraperitoneal routes.
    • To compare the interaction of 1,2-DCE with DSF to that of EDB with DSF.

    Main Methods:

    • Rats were exposed to 1,2-DCE via inhalation or intraperitoneal injection while fed a diet containing DSF.
    • Dose-response relationships and toxicological endpoints (testicular atrophy, liver and spleen histopathology, body weight changes) were assessed.

    Related Experiment Videos

  • Control groups received either 1,2-DCE or DSF alone.

    • Main Results:

    • Combined exposure to 1,2-DCE and DSF resulted in testicular atrophy and liver histopathology at lower 1,2-DCE doses compared to 1,2-DCE alone.
    • DSF lowered the threshold for 1,2-DCE-induced liver enlargement, decreased liver/body weight ratios, and reduced body weight gain.
    • A decrease in spleen weight was observed in the intraperitoneal study.
    • The toxic effects observed were similar to those seen with EDB and DSF, but required higher doses of 1,2-DCE.

    Conclusions:

    • 1,2-DCE interacts synergistically with DSF, potentiating its toxicity, particularly affecting the testes and liver.
    • DSF significantly lowers the dose at which adverse effects of 1,2-DCE manifest.
    • The findings suggest a shared toxicological mechanism between 1,2-DCE and EDB in their interaction with DSF, albeit with different potencies.