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Updated: Aug 1, 2025

Synthesis and Characterization of mRNA-Loaded PolyBeta Aminoesters Nanoparticles for Vaccination Purposes
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mRNA vaccination in breast cancer: current progress and future direction

Xiao-Ting Jiang1, Qiang Liu2

  • 1Breast Tumor Center, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, 107 Yanjiang West Road, Guangzhou, 510120, China.

Journal of Cancer Research and Clinical Oncology
|April 26, 2023
PubMed

Insights

Messenger RNA (mRNA) vaccination shows promise for breast cancer immunotherapy by converting non-responsive tumors into responsive ones. Further research into vaccine design and combination therapies is crucial for improving patient outcomes.

Area of Science:

  • Oncology
  • Immunology
  • Biotechnology

Background:

  • Messenger RNA (mRNA) vaccination is a successful strategy against COVID-19 and a promising area for cancer immunotherapy.
  • Breast cancer, a prevalent malignancy in women, has limited patient access to current immunotherapy benefits.
  • mRNA technology offers potential to enhance immunotherapy response rates in breast cancer by modulating the tumor microenvironment.

Purpose of the Study:

  • To review pre-clinical and clinical data on mRNA vaccination platforms for breast cancer.
  • To discuss strategies for optimizing mRNA vaccine design and delivery for breast cancer treatment.
  • To explore combination approaches of mRNA vaccines with other immunotherapies to improve treatment efficacy.

Main Methods:

  • Review of existing pre-clinical and clinical studies on mRNA vaccines for breast cancer.
  • Analysis of factors influencing in vivo mRNA vaccine function, including targets, structures, vectors, and delivery routes.
  • Exploration of synergistic effects by combining mRNA vaccination with other immunotherapeutic modalities.

Main Results:

  • mRNA vaccines demonstrate potential to transform "cold" breast tumors into immunologically "hot" ones, increasing treatment responsiveness.
  • Various mRNA vaccination platforms are under investigation for their efficacy in breast cancer models.
  • Considerations for effective vaccine design include target selection, mRNA structure optimization, and appropriate delivery systems.

Conclusions:

  • mRNA vaccination represents a significant advancement with the potential to overcome immunotherapy resistance in breast cancer.
  • Optimizing mRNA vaccine design and delivery is key to maximizing therapeutic benefits.
  • Combination strategies involving mRNA vaccines and other immunotherapies may significantly improve treatment outcomes for breast cancer patients.
Keywords:
Breast cancerCancer vaccinemRNA vaccination

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