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Effects of hormones on intestinal stem cells
Li Liu1, Lilong Zhang1, Chunlei Li1
1Department of General Surgery, Renmin Hospital of Wuhan University, Wuhan, Hubei, China.
Stem Cell Research & Therapy
|April 26, 2023
Summary
Hormones significantly influence intestinal stem cells (ISCs), impacting renewal, repair, and tumor growth. Understanding these hormonal effects offers new therapeutic targets for intestinal diseases.
Area of Science:
- Gastroenterology and Endocrinology
Background:
- Intestinal stem cells (ISCs) are crucial for maintaining intestinal renewal and repair.
- ISCs also play a role in the development of intestinal tumors.
- Hormones act as key signaling agents influencing ISC behavior.
Purpose of the Study:
- To review recent advancements in identifying hormones that interact with intestinal stem cells.
- To explore the dual role of hormones in promoting or inhibiting ISC proliferation.
Main Methods:
- Literature review of studies identifying hormones affecting intestinal stem cells.
- Analysis of the mechanisms by which specific hormones influence ISC development and proliferation.
Main Results:
- Several hormones, including thyroid hormone, glucagon-like peptide-2, androgens, insulin, leptin, growth hormone, corticotropin-releasing hormone, and progastrin, promote ISC development.
- Somatostatin and melatonin were identified as hormones that inhibit ISC proliferation.
Conclusions:
- Hormonal regulation is a critical factor in intestinal stem cell dynamics.
- Targeting specific hormones offers potential new therapeutic strategies for intestinal diseases and disorders.
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