Back to the Basics: Developing Advanced Metal-Organic Frameworks Using Fundamental Chemistry Concepts.

Area of Science:

• Materials Science
• Chemistry
• Nanotechnology

Background:

• Metal-organic frameworks (MOFs) have evolved significantly over 25 years.
• MOFs are crystalline porous materials with tunable physical properties based on building block selection.
• Fundamental coordination chemistry principles underpin the design of stable MOF structures.

Purpose of the Study:

• To provide an overview of MOF design strategies.
• To discuss how fundamental chemistry concepts are leveraged to synthesize highly crystalline MOFs.
• To highlight design principles for accessing stable MOF structures through literature examples.

Main Methods:

• Review of fundamental coordination chemistry design principles.
• Analysis of literature examples showcasing MOF synthesis and stability.
• Discussion of parameter tuning for crystalline MOF formation.

Main Results:

• Established design strategies based on fundamental chemistry.
• Demonstrated the link between chemistry principles and MOF stability/crystallinity.
• Highlighted key factors for successful MOF structure synthesis.

Conclusions:

• Fundamental chemistry provides a strategic basis for MOF design.
• Continued application of these principles will enable advanced MOFs with tailored properties.
• The field anticipates future development of even more sophisticated MOF structures.