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Triple Threat: Three Primary Malignancies Simultaneously Involving Three Genitourinary Organs.

Katharina Mitchell¹, Reima El Naili², Lakshmikumar Pillai³

¹West Virginia University Department of Urology, Morgantown, WV, USA.

Case Reports in Urology

|April 27, 2023

Summary

This case report details an extremely rare occurrence of three distinct cancers: renal cell carcinoma (RCC), urothelial carcinoma of the bladder (UC), and a renal neuroendocrine tumor (NET). The patient presented with symptoms of these concurrent malignancies.

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Using the Chicken Chorioallantoic Membrane In Vivo Model to Study Gynecological and Urological Cancers

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Published on: January 28, 2020

Area of Science:

Oncology
Urology
Pathology

Background:

Concurrent malignancies are rare, with the simultaneous occurrence of renal cell carcinoma (RCC), urothelial carcinoma of the bladder (UC), and renal neuroendocrine tumor (NET) being exceptionally uncommon.
This report highlights a statistically improbable case, emphasizing the importance of comprehensive diagnostic evaluation in complex presentations.

Observation:

A 67-year-old female presented with bilateral flank pain and gross hematuria.
Imaging revealed bilateral renal masses and a paracaval lymph node. Cystoscopy identified a bladder tumor.
Biopsies confirmed clear cell RCC (left kidney), well-differentiated NET (right kidney), and high-grade nonmuscle invasive UC (bladder).

Findings:

Final pathology confirmed three distinct malignancies: noninvasive high-grade papillary UC (pTaN0), left renal clear cell RCC (pT2bN0), and right renal well-differentiated NET with metastatic disease to a paracaval lymph node (pT2aN1).
The patient underwent bilateral nephroureterectomy, radical cystectomy, and lymphadenectomy.

Implications:

This case underscores the possibility of multiple, rare primary malignancies occurring concurrently in a single patient.
It highlights the need for thorough investigation of complex urological and renal symptoms, even in the face of statistically improbable diagnoses.
Such rare occurrences contribute valuable data to understanding cancer development and presentation.