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The Association Between Chronological Age and Dyslipidemia: A Cross-Sectional Study in Chinese Aged Population
Qingyao Li1,2, Ying Jiang2, Anqi Song2
1Department of Preventive Medicine, School of Public Health, North China University of Science and Technology, Tangshan, People's Republic of China.
Insights
Chronological age is linked to dyslipidemia risk in older Chinese adults. Older age groups showed a decreased likelihood of dyslipidemia, indicating a complex relationship.
Area of Science:
- Gerontology
- Cardiovascular Health
- Metabolic Disorders
Background:
- Dyslipidemia is a significant risk factor for cardiovascular diseases, particularly impacting the elderly population.
- Cardiovascular diseases can lead to disability and mortality in aged individuals.
- Understanding the relationship between age and dyslipidemia is crucial for public health strategies.
Purpose of the Study:
- To investigate the association between chronological age and the prevalence of dyslipidemia.
- To analyze age-specific risks of dyslipidemia in a large cohort of Chinese elderly individuals.
Main Methods:
- A cross-sectional study included 59,716 Chinese aged individuals (average age 67.8 years).
- Data on demographics, anthropometrics, blood pressure, and serum lipid profiles (total cholesterol, triglycerides) were collected.
- Dyslipidemia was defined based on lipid levels or self-reported history.
Main Results:
- The overall prevalence of dyslipidemia was 50.4% in the study population.
- Older age groups exhibited a reduced odds ratio for dyslipidemia compared to the youngest group (60-64 years).
- Adjusted odds ratios decreased progressively with increasing age, showing a significant trend (p < 0.001).
Conclusions:
- Chronological age demonstrates a significant association with dyslipidemia risk in the Chinese aged population.
- The findings suggest an inverse relationship between advanced age and dyslipidemia prevalence in this demographic.
- Further research may explore the underlying mechanisms contributing to this age-related pattern.
Background And Aims:
Dyslipidemia is obviously an important risk factor for cardiovascular diseases, which might further lead to disability and death in aged population. We thus performed the current study to evaluate the association between chronological age and dyslipidemia.
Subjects And Methods:
A total number of 59,716 Chinese aged population (31,174 men and 28,542 women, average age 67.8y) were included in the current study. Age and sex were abstracted from medical records. Height, body weight, and blood pressure were measured by trained nurses. Serum concentration of total cholesterol (TC) and total triglycerides were performed by enzyme-linked immunosorbent method after at least 8-h fast. Dyslipidemia was defined if total cholesterol≥5.7 mmol/L, or total triglycerides≥1.7 mmol/L, or self-reported history of dyslipidemia.
Results:
The prevalence of dyslipidemia was 50.4% in the current study population. Compared to the youngest age group (60-64y), the adjusted odds ratio was 0.88 (95% CI: 0.84, 0.92), 0.77 (95% CI: 0.73, 0.81), 0.66 (95% CI: 0.61, 0.70), 0.55 (95% CI: 0.50, 0.59) for the participants who were 65 to 69, 70-74, 75-79, and ≥80 years old (p trend <0.001). Excluding participants with low body weight and with overweight and obesity, with high blood pressure and history of hypertension, with high fasting blood glucose and history of diabetes, generated similar results with main analysis.
Conclusion:
Chronological age was closely associated with the risk of dyslipidemia in Chinese aged population.
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