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Author Spotlight: Exploring Autism Spectrum Disorder Symptoms in Fruit Flies — Genetic Models and Behavioral Tests
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Correlation of mutated gene and signalling pathways in ASD

Madhavi Apte1, Aayush Kumar2

  • 1Quality Assurance and Pharmacognosy and Phytochemistry, SVKM's Dr. Bhanuben Nanavati College of Pharmacy, Vile Parle, 400056 Mumbai, India.

IBRO Neuroscience Reports
|April 27, 2023
PubMed

Insights

Autism spectrum disorder involves complex genetics affecting brain development and cognition. This review explores genetic factors, protein roles, and therapeutic approaches like cognition-behavior therapy for autism.

Area of Science:

  • Neuroscience
  • Genetics
  • Developmental Psychology

Background:

  • Autism spectrum disorder (ASD) is a neurodevelopmental condition affecting social interaction and communication, with global prevalence.
  • In India, over 18 million individuals are diagnosed with ASD.
  • Worldwide, 1 in 160 children have ASD, highlighting its significant public health impact.

Purpose of the Study:

  • To review the complex genetic architecture underlying autism spectrum disorder.
  • To summarize the roles of specific proteins implicated in ASD development.
  • To examine how genetic mutations impact brain circuitry and cognitive development, including theory of mind.

Main Methods:

  • Literature review of genetic studies on autism.
  • Analysis of protein functions related to neurodevelopment.
  • Exploration of signaling pathways affected by genetic mutations.
  • Review of cognitive development and theory of mind research in ASD.

Main Results:

  • Autism is characterized by a complex genetic basis influencing neurodevelopment.
  • Specific proteins and convergent signaling pathways are critical in ASD pathogenesis.
  • Genetic mutations can disrupt brain circuitry development, impacting cognition and social understanding.

Conclusions:

  • Understanding the genetic and molecular underpinnings of ASD is crucial for developing targeted interventions.
  • Cognition-behavior therapy shows promise in addressing cognitive and behavioral challenges in individuals with autism.
  • Further research into genetic factors and their impact on brain development is essential for improving outcomes for those with ASD.

Keywords:
AutismCognition developmentCognitive behavioral therapyEpigenetic RegulationGene mutationGenetic architectureGeneticsSignaling pathwayTheory of mind

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