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Intramuscular Injections Along the Motor End Plates: A Minimally Invasive Approach to Shuttle Tracers Directly into Motor Neurons
10:57

Intramuscular Injections Along the Motor End Plates: A Minimally Invasive Approach to Shuttle Tracers Directly into Motor Neurons

Published on: July 13, 2015

Motor endplate involvement in the extraocular muscles of the myotonic rat

B R Pachter, A Eberstein

    Graefe'S Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Fur Klinische Und Experimentelle Ophthalmologie
    |January 1, 1986
    PubMed

    Abstract:

    The motor endplates from the extraocular muscles of rats administered 20,25-diazacholesterol were examined by electron microscopy. Many anomalies were found at various levels of the junctional complex. Electron microscopy showed disrupted sole-plate nuclei, disruptions of the junctional sarcoplasm, atypical sarcoplasmic extensions, simplified postsynaptic areas, and interposition of Schwann cell cytoplasm between axonal terminal and muscle fiber with a reduplication of basement membrane, as well as atrophic and disrupted axonal terminals. These data indicate that the motor endplate is affected as well as the muscle fiber in myotonic dystrophy.

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