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Glomerular Diseases in the Colombian Caribbean: Data from the Colombian Nephropathy Registry (NEFRORED®)

Gustavo Aroca-Martínez1, Henry J González-Torres2, Alex Domínguez-Vargas3

  • 1Faculty of Health Sciences, Simón Bolívar University; Department of Nephrology, Clínica de la Costa, Barranquilla, Colombia.

Saudi Journal of Kidney Diseases and Transplantation : an Official Publication of the Saudi Center for Organ Transplantation, Saudi Arabia
|April 27, 2023
PubMed

Insights

This study of Colombian Caribbean kidney biopsies reveals secondary glomerular diseases are more common than primary types. Lupus nephritis was the leading cause of secondary disease.

Area of Science:

  • Nephrology
  • Pathology
  • Epidemiology

Background:

  • Glomerular diseases represent a significant cause of kidney disease globally.
  • Understanding regional variations in glomerular disease prevalence is crucial for targeted interventions.
  • The Colombian Nephropathy Registry (NEFRORED®) provides a unique dataset for this analysis.

Purpose of the Study:

  • To characterize the spectrum of primary glomerular disease (PGD) and secondary glomerular disease (SGD) in the Colombian Caribbean.
  • To identify the most frequent etiologies within PGD and SGD categories.
  • To assess renal survival prognosis in patients with specific glomerular diseases.

Main Methods:

  • A descriptive, retrospective study utilizing data from the NEFRORED® registry.
  • Analysis of 871 renal biopsies (light microscopy and immunofluorescence) from January 2008 to June 2018.
  • Evaluation of clinical indications for biopsy and 24-month renal survival outcomes.

Main Results:

  • Secondary glomerular disease (55%) was more prevalent than primary glomerular disease (45%).
  • Lupus nephritis was the predominant cause of SGD (83%), while membranous nephropathy (33%) and focal segmental glomerulosclerosis (FSGS) (19%) were most common in PGD.
  • Nephritic syndrome was the primary indication for renal biopsy (36%).
  • Patients with FSGS and paraproteinemia-mediated glomerular disease exhibited poorer renal survival.

Conclusions:

  • The Colombian Caribbean region shows a high predominance of secondary glomerular diseases, largely driven by lupus nephritis.
  • This registry represents the first regional data on glomerular diseases in this population.
  • FSGS and paraproteinemia-mediated glomerular disease require close monitoring due to adverse renal outcomes.

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