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Exploring the Effects of Spaceflight on Mouse Physiology using the Open Access NASA GeneLab Platform

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Metagenomic Methods for Addressing NASA's Planetary Protection Policy Requirements on Future Missions: A Workshop

Stefan J Green¹, Tamas Torok², Jonathan E Allen³

¹Genomics and Microbiome Core Facility, Rush University Medical Center, Chicago, Illinois, USA.

|April 27, 2023

Summary

New molecular biology techniques, including metagenomics, can significantly enhance planetary protection (PP) by providing rapid and comprehensive microbial analysis for spacecraft. These advanced methods are recommended to supplement current assays by 2026.

Keywords:

Contamination DNA Metagenomics Planetary protection Spacecraft Assembly Facility

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Last Updated: Aug 1, 2025

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Prospecting Microbial Strains for Bioremediation and Probiotics Development for Metaorganism Research and Preservation

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Published on: October 31, 2019

Area of Science:

Space exploration
Planetary protection
Microbiology

Background:

Planetary protection (PP) relies on established assays for microbial detection on spacecraft.
Advancements in molecular biology offer potential improvements to current PP methods.
NASA convened a workshop to explore the integration of modern molecular techniques into PP.

Purpose of the Study:

Assess the feasibility of applying modern molecular techniques to planetary protection.
Modernize and supplement existing PP assays with advanced molecular methods.
Identify knowledge and technology gaps for implementing new techniques.

Main Methods:

Held the Multi-Mission Metagenomics Technology Development Workshop.
Focused discussions on metagenomics and other advanced molecular techniques.
Evaluated metagenomics as a stand-alone and supplementary tool for PP.

Main Results:

Metagenomics recommended as a data source for quantitative microbial risk assessment.
Metagenomics combined with digital PCR offers a revolutionary advance over current methods.
Key technology development areas identified: low biomass sampling, reagent contamination, and bioinformatics analysis.

Conclusions:

Modern molecular methods, particularly metagenomics, should be incorporated into standard PP protocols.
Implementing metagenomics will significantly improve microbial bioburden assessment for robotic missions.
These advancements will benefit future missions by mitigating forward and backward contamination risks.