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Updated: Aug 1, 2025

A Simplified Model for Heterotopic Heart Valve Transplantation in Rodents
Published on: September 21, 2021
Growing Heart Valve Implants for Children
Haley Konsek1, Curry Sherard1, Cora Bisbee1
1Department of Surgery, College of Medicine, Medical University of South Carolina, Charleston, SC 29425, USA.
Abstract:
The current standard of care for pediatric patients with unrepairable congenital valvular disease is a heart valve implant. However, current heart valve implants are unable to accommodate the somatic growth of the recipient, preventing long-term clinical success in these patients. Therefore, there is an urgent need for a growing heart valve implant for children. This article reviews recent studies investigating tissue-engineered heart valves and partial heart transplantation as potential growing heart valve implants in large animal and clinical translational research. In vitro and in situ designs of tissue engineered heart valves are discussed, as well as the barriers to clinical translation.
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