Related Experiment Video
Updated: Aug 1, 2025

A Bioluminescent and Fluorescent Orthotopic Syngeneic Murine Model of Androgen-dependent and Castration-resistant Prostate Cancer
Published on: March 6, 2018
Understanding Prescribing Differences Between Urologists and Medical Oncologists in the Management of Advanced
Timothy Demus1, Robert H Getzenberg2, Alan M Nieder1
1Columbia University Division of Urology at Mount Sinai Medical Center, Miami Beach, Florida.
Urologists are nearly 5 times more likely to prescribe enzalutamide over abiraterone for advanced prostate cancer. Understanding these prescribing differences between urologists and medical oncologists is crucial for patient care.
Area of Science:
- Oncology
- Urology
- Pharmacology
Background:
- Oral therapies enable continued patient care for advanced prostate cancer with castration resistance.
- Prescribing patterns for these advanced prostate cancer oral therapies vary between specialties.
Purpose of the Study:
- To compare the prescribing practices of urologists and medical oncologists for oral advanced prostate cancer therapies.
- To identify factors influencing prescribing preferences between enzalutamide and abiraterone.
Main Methods:
- Utilized Medicare Part D Prescribers data (2013-2019).
- Classified physicians as enzalutamide or abiraterone prescribers based on prescription volume.
- Employed generalized linear regression to analyze prescribing determinants.
Main Results:
- In 2019, urologists were significantly more likely to prescribe enzalutamide (OR 4.91).
- Urologists were more likely to prescribe generic abiraterone (37.9%) compared to medical oncologists (62.5%).
Conclusions:
- Significant prescribing differences exist between urologists and medical oncologists in advanced prostate cancer treatment.
- Further understanding of these disparities is essential for healthcare.
- These findings highlight potential variations in treatment selection and generic drug utilization.
More Related Videos
Related Concept Videos
Disorders of the Male Reproductive System
Prostate disorders are another major concern. These conditions can impair urinary flow due to the prostate's location around the urethra....
Urinary Tract Calculi III: Medical Management
Targeted Cancer Therapies
There are several types of targeted therapies against...
Cancer Survival Analysis
Cancer Therapies
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
Combination Therapies and Personalized Medicine
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...

