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A Closed-Type Wireless Nanopore Electrode for Analyzing Single Nanoparticles
Published on: March 20, 2019
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Solid-State Nanopore/Nanochannel Sensing of Single Entities
Wei Yi1, Chuanping Zhang2, Qianchun Zhang1
1School of Biology and Chemistry, Minzu Normal University of Xingyi, Xingyi, 562400, People's Republic of China.
Topics in Current Chemistry (Cham)
|April 27, 2023
Summary
Solid-state nanopores offer sensitive single-entity detection for biosensors. This review explores their preparation, functionalization, and novel strategies to overcome limitations like pore blockage and low flux for improved electrochemical sensing.
Area of Science:
- Nanotechnology
- Biosensing
- Electrochemistry
Background:
- Solid-state nanopores/nanochannels are advanced tools for biosensor construction due to stability and tunable properties.
- They offer high sensitivity, specificity, and resolution for detecting single entities via nanoconfined target enrichment.
Purpose of the Study:
- To review the preparation and functionalization of solid-state nanopores/nanochannels.
- To discuss current research in single-entity sensing using these platforms.
- To introduce novel strategies addressing limitations in solid-state nanopore sensing.
Main Methods:
- Inner wall modification of solid-state nanopores/nanochannels.
- Detection principles including resistive pulse and steady-state ion current methods.
- Review of existing literature and novel sensing strategies.
Main Results:
- Solid-state nanopores enable sensitive detection of single molecules, particles, and cells.
- Common challenges include pore blockage by targets and interference from other substances.
- Low flux rates can also limit detection efficiency.
Conclusions:
- Solid-state nanopores show great promise for single-entity electrochemical sensing.
- Overcoming current limitations is crucial for broader application.
- Future research should focus on enhanced sensing strategies and improved flux.
