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Updated: Aug 1, 2025

In Silico Identification and Characterization of circRNAs During Host-Pathogen Interactions
10:27

In Silico Identification and Characterization of circRNAs During Host-Pathogen Interactions

Published on: October 21, 2022

1.6K

CircRNAs and RNA-Binding Proteins Involved in the Pathogenesis of Cancers or Central Nervous System Disorders

Yuka Ikeda1, Sae Morikawa1, Moeka Nakashima1

  • 1Department of Food Science and Nutrition, Nara Women's University, Kita-Uoya Nishimachi, Nara 630-8506, Japan.

Non-Coding RNA
|April 27, 2023
PubMed

Insights

Circular RNAs (circRNAs) are key regulators of gene expression and disease pathogenesis. Their unique structure and function offer potential for novel diagnostic and therapeutic strategies.

Area of Science:

  • Molecular Biology
  • Genetics
  • Biochemistry

Background:

  • Circular RNAs (circRNAs) are novel noncoding RNA transcripts with a unique covalently closed loop structure.
  • They function as crucial post-transcriptional and post-translational regulators, influencing cellular signaling and gene expression.
  • Aberrant circRNA expression is implicated in the pathogenesis of various diseases.

Purpose of the Study:

  • To review current findings on circRNAs in disease.
  • To explore the theragnostic potential of circRNAs.
  • To provide insights for developing novel diagnostic and therapeutic strategies.

Main Methods:

  • Literature review of current research on circRNAs.
  • Analysis of circRNA roles in cellular signaling and gene regulation.
  • Evaluation of circRNA involvement in disease pathogenesis.
  • Assessment of circRNA stability, abundance, and blood-brain barrier crossing capabilities.

Main Results:

  • CircRNAs act as miRNA sponges, regulating gene expression at the post-transcriptional level.
  • CircRNAs, microRNAs, and RNA-binding proteins are key gene modulators linked to disease.
  • CircRNAs exhibit stability, high abundance in the brain, and can cross the blood-brain barrier.

Conclusions:

  • CircRNAs hold significant potential as diagnostic biomarkers and therapeutic targets for various diseases.
  • Further research into circRNAs can drive the development of innovative medical strategies.
  • Understanding circRNA mechanisms is crucial for advancing disease treatment and diagnostics.
Keywords:
APRO family proteinRNA binding proteincircular RNApoly(A)-binding proteintranslational regulator

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