Linalool prevents kidney damage by inhibiting rifampicin-induced oxidative stress and apoptosis

Area of Science:

• Nephrology
• Pharmacology
• Toxicology

Background:

• Acute kidney injury (AKI) is a significant clinical problem, often linked to antibiotic use.
• Rifampicin (RF), a vital antibiotic, can induce kidney damage via oxidative stress and apoptosis.
• Linalool (LN) possesses known antioxidant and anti-inflammatory properties.

Purpose of the Study:

• To investigate the protective effects of linalool (LN) against rifampicin-induced (RF) kidney injury.
• To evaluate LN's potential to mitigate RF's adverse effects on kidney function and tissue integrity.

Main Methods:

• Rats were administered RF to induce kidney injury.
• Separate groups received RF with or without LN.
• Key biomarkers of kidney injury (NGAL mRNA, creatinine, BUN, Caspase 9, NF-κB) and kidney function (albumin, uric acid, total protein) were measured.

Main Results:

• RF administration significantly increased kidney injury markers (NGAL mRNA, Cr, BUN, CAS-9, NF-κB) and decreased kidney function markers (albumin, uric acid, total protein).
• Co-administration of LN with RF markedly reduced elevated injury markers and restored decreased function markers.
• LN demonstrated significant efficacy in preventing RF-induced kidney tissue damage.

Conclusions:

• Linalool exhibits significant protective effects against acute kidney injury induced by rifampicin.
• LN mitigates RF-induced nephrotoxicity by combating oxidative stress and apoptosis.
• LN represents a potential therapeutic agent for preventing or treating antibiotic-induced kidney damage.