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Allergic Reactions02:06

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Allergic reactions related to drugs are hypersensitivity responses driven by the immune system and bear no connection to the drug's therapeutic action. While drugs in isolation do not trigger an immune response, they can interact with endogenous proteins to form antigens. These antigens stimulate lymphocytes to produce antibodies. IgE-type antibodies attach themselves to mast cells. Upon subsequent exposure to the same stimulus, the antigen-antibody interaction is initiated, unleashing...
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Hypersensitivity, also known as a hypersensitivity reaction or allergic reaction, is a condition where the body's immune system reacts abnormally to a foreign substance. Such substances, that cause hypersensitivity are referred to as an allergen, could be something typically harmless to most people, like pollen or certain foods.
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Antibodies, also known as immunoglobulins (Ig), are essential players of the adaptive immune system. These antigen-binding proteins are produced by B cells and make up 20 percent of the total blood plasma by weight. In mammals, antibodies fall into five different classes, which each elicits a different biological response upon antigen binding.
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Conditioned taste aversion, also known as sauce béarnaise syndrome, is a phenomenon in which an individual develops an aversion to a certain food taste following a negative experience, typically illness. This form of aversion is a type of classical conditioning in which the taste of the food (conditioned stimulus, CS) is associated with the experience of illness (unconditioned stimulus, UCS).
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Related Experiment Video

Updated: Aug 1, 2025

Application of Biochip Microfluidic Technology to Detect Serum Allergen-specific Immunoglobulin E sIgE
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Food Allergy.

Chelsea Elizabeth Mendonca1, Doerthe A Andreae2

  • 1Department of Family and Community Medicine, Baylor College of Medicine, 1100 West 34th Street, Houston, TX 77018, USA.

Primary Care
|April 27, 2023
PubMed
Summary
This summary is machine-generated.

Food allergies are a common health issue affecting all ages. While treatments like oral immunotherapy show promise, avoiding trigger foods and using epinephrine autoinjectors remain key management strategies.

Keywords:
AnaphylaxisEpinephrine autoinjectorsFood allergyIgE mediatedSkin prick test

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Area of Science:

  • Allergy and Immunology
  • Clinical Medicine

Background:

  • Food allergy is a significant and increasing global health concern impacting both children and adults.
  • Food allergies can be mediated by immunoglobulin E (IgE) or non-IgE mechanisms, leading to diverse clinical presentations.

Purpose of the Study:

  • To review the current understanding and management of food allergies.
  • To highlight diagnostic approaches and therapeutic options for food allergies.

Main Methods:

  • Diagnosis involves a comprehensive approach combining clinical history, reaction assessment, skin prick tests, IgE testing, and oral food challenges.
  • Treatment strategies discussed include food avoidance, emergency preparedness with epinephrine autoinjectors, and emerging therapies like oral immunotherapy.

Main Results:

  • Oral immunotherapy has demonstrated success in inducing sustained unresponsiveness in a subset of patients.
  • Currently, no definitive cure for food allergies exists.

Conclusions:

  • Effective management of food allergies relies on accurate diagnosis, strict avoidance of allergens, and prompt administration of epinephrine in emergencies.
  • Ongoing research into therapies like oral immunotherapy offers hope for improved long-term patient outcomes.