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Updated: Aug 1, 2025

A Multicenter MRI Protocol for the Evaluation and Quantification of Deep Vein Thrombosis
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Six-Month Deep Vein Thrombosis Outcomes by Chronicity: Analysis of the Real-World ClotTriever Outcomes Registry

Steven D Abramowitz1, Herman Kado2, Jonathan Schor3

  • 1MedStar Health, Washington, DC.

Journal of Vascular and Interventional Radiology : JVIR
|April 27, 2023
PubMed

Insights

Mechanical thrombectomy with the ClotTriever System effectively treats acute, subacute, and chronic deep vein thrombosis (DVT). This real-world study shows significant improvements in patient outcomes and quality of life across all DVT types.

Area of Science:

  • Vascular Surgery
  • Interventional Cardiology
  • Medical Device Technology

Background:

  • Deep vein thrombosis (DVT) is a significant vascular condition affecting millions globally.
  • Current treatment modalities for DVT, including anticoagulation and thrombolysis, have limitations.
  • Mechanical thrombectomy offers a minimally invasive approach to DVT treatment.

Purpose of the Study:

  • To evaluate the safety and effectiveness of the ClotTriever System for mechanical thrombectomy in patients with acute, subacute, and chronic deep vein thrombosis (DVT).
  • To analyze real-world outcomes from the prospective, multicenter ClotTriever Outcomes (CLOUT) registry.

Main Methods:

  • Prospective, multicenter registry of 250 patients with lower extremity DVT treated with the ClotTriever System.
  • Thrombus chronicity (acute, subacute, chronic) determined by visual inspection.
  • Assessment of serious adverse events (SAEs) through 30 days and clinical/quality-of-life outcomes through 6 months.

Main Results:

  • High rates of complete or near-complete thrombus removal (81.9%–90.8%) across all DVT chronicity groups.
  • Significant improvements in Villalta scores (P < .0001) and EQ-5D scores (P < .0001) at 6 months.
  • One device-related SAE (fatal pulmonary embolism) occurred in the subacute group; outcomes were similar across subgroups.

Conclusions:

  • Mechanical thrombectomy using the ClotTriever System is a safe and effective treatment for acute, subacute, and chronic DVT.
  • The procedure demonstrates consistent efficacy and positive patient outcomes regardless of thrombus chronicity.
  • Adjunctive venoplasty and stent placement can be utilized at physician discretion.
Abstract

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