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Development of pH-Responsive Polypills via Semi-Solid Extrusion 3D Printing.

Fan Wang¹, Ling Li¹, Xiaolong Zhu¹

¹National Engineering Research Center for High-Efficiency Grinding, College of Mechanical and Vehicle Engineering, Hunan University, Changsha 410082, China.

Bioengineering (Basel, Switzerland)

|April 28, 2023

Summary

This study introduces 3D-printed pH-responsive hydrogel drug carriers for improved oral drug bioavailability. Material ratios control drug release in the stomach or intestines, enhancing targeted delivery.

Keywords:

carboxymethyl chitosan pH-responsive medicine personalised medicine semi-solid extrusion sodium alginate

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Area of Science:

Pharmaceutical Sciences
Biomaterials Engineering
Drug Delivery Systems

Background:

Low oral drug bioavailability is a major challenge due to gastrointestinal instability.
Site-targeted drug delivery systems require carriers stable in diverse pH environments.
Developing customizable drug release profiles is crucial for therapeutic efficacy.

Purpose of the Study:

To develop a novel 3D-printed hydrogel drug carrier using pH-responsive materials.
To enable site-targeted drug release and customize temporal release profiles for oral administration.
To investigate the impact of material parameters on hydrogel swelling and drug release.

Main Methods:

Utilized semi-solid extrusion 3D printing technology with pH-responsive hydrogels.
Analyzed swelling properties of printed tablets in artificial gastric and intestinal fluids.
Investigated the effects of sodium alginate and carboxymethyl chitosan mass ratios.
Performed drug release experiments to assess site-specific and controlled release.

Main Results:

Adjusting the sodium alginate to carboxymethyl chitosan mass ratio significantly altered pH-responsive swelling.
A 1:3 ratio facilitated gastric drug release, while a 3:1 ratio enabled intestinal release.
Infill density tuning allowed for controlled drug release kinetics.
Achieved site-targeted drug release based on material composition and printing parameters.

Conclusions:

The 3D-printed pH-responsive hydrogel carrier system effectively addresses oral drug instability and low bioavailability.
This technology allows for precise control over drug release location (gastric or intestinal) and timing.
Offers potential for customized drug delivery and controlled release of individual components in multi-drug formulations.