Related Experiment Video
Updated: Aug 1, 2025
09:37
A Phenotyping Regimen for Genetically Modified Mice Used to Study Genes Implicated in Human Diseases of Aging
Published on: July 14, 2016
8.3K
Humanin and Its Pathophysiological Roles in Aging: A Systematic Review
Donatella Coradduzza1, Antonella Congiargiu1, Zhichao Chen1
1Department of Biomedical Sciences, University of Sassari, 07100 Sassari, Italy.
Biology
|April 28, 2023
Summary
Cellular senescence, a hallmark of aging, involves declining function and increased damage. Humanin, a peptide, may counteract aging processes and age-related diseases by preserving cell viability and function.
Area of Science:
- Cellular Biology
- Gerontology
- Biochemistry
Background:
- Senescence is a fundamental aging process characterized by cellular dysfunction, proliferation decline, and increased damage.
- Mitochondrial-derived peptide Humanin offers cytoprotection, preserving mitochondrial function and cell viability during stress and senescence.
- Both senescence and Humanin are implicated in age-related diseases like cardiovascular conditions, neurodegeneration, and cancer.
Purpose of the Study:
- To systematically review the mechanisms linking senescence, Humanin, aging, and disease.
- To elucidate the complex interplay between cellular aging and Humanin's protective roles.
Main Methods:
- Systematic literature review.
- Analysis of existing research on senescence and Humanin.
- Synthesis of findings on their roles in aging and disease.
Main Results:
- Senescent cells contribute to age-related diseases through inflammatory pathways.
- Humanin demonstrates potential in counteracting senescence-associated pathologies.
- Further research is needed to fully clarify these complex mechanisms and therapeutic potential.
Conclusions:
- Senescence and Humanin are critical factors in aging and age-related diseases.
- Humanin's cytoprotective and anti-inflammatory properties offer therapeutic avenues.
- Understanding these mechanisms is key to developing interventions for age-related conditions.
More Related Videos
Related Concept Videos
01:26Aging
92
Aging is a complex biological phenomenon influenced by various processes that affect cellular and systemic functions. Several prominent theories attempt to explain its mechanisms, highlighting cellular limitations, oxidative damage, and hormonal changes as central factors in aging.
Cellular Clock Theory
The cellular clock theory posits that the human lifespan is closely tied to the finite capacity of cells to divide, a phenomenon governed by telomeres, which are protective caps at the ends of...
Cellular Clock Theory
The cellular clock theory posits that the human lifespan is closely tied to the finite capacity of cells to divide, a phenomenon governed by telomeres, which are protective caps at the ends of...
92
01:37Mitochondria
14.0K
Mitochondria are eukaryotic cellular organelles that are known to produce energy through a process called oxidative phosphorylation. Besides their primary function, mitochondria are involved in various cellular processes, including cell growth, differentiation, signaling, metabolism, and senescence. Age-related changes cause a decline in mitochondrial quality and integrity due to increased mitochondrial mutations and oxidative damage. Thus, aging can severely impact mitochondrial functions,...
14.0K
01:19The Effect of Aging on Tissues
2.2K
Several body functions deteriorate with age. The external signs of aging are easily identifiable. For example, the skin becomes dry, less elastic, and thins out, forming wrinkles. The skin of the face begins to appear looser due to a decrease in the levels of elastic and collagen fibers in the connective tissue. Additionally, melanin production in the hair follicle decreases with age, resulting in gray hair. Moreover, the senses of sight and hearing decline, so glasses and hearing aids may...
2.2K