Tubulin Post-Translational Modifications: The Elusive Roles of Acetylation
Bruno Carmona1,2, H Susana Marinho3, Catarina Lopes Matos1
1Centro de Química Estrutural, Institute of Molecular Sciences, Faculdade de Ciências, Universidade de Lisboa, Campo Grande, 1749-016 Lisboa, Portugal.
Biology
|April 28, 2023
Summary
Tubulin acetylation, a key post-translational modification, impacts microtubule stability and flexibility. This review explores its roles in cell biology, stress response, and human pathologies.
Area of Science:
- Cell Biology
- Molecular Biology
- Biochemistry
Background:
- Microtubules (MTs) are essential eukaryotic polymers involved in diverse cellular processes.
- Post-translational modifications (PTMs) of tubulin, such as acetylation, diversify MT functions.
- Tubulin acetylation's precise roles remain under investigation.
Purpose of the Study:
- To review the current understanding of tubulin acetylation.
- To discuss the regulation and cellular impacts of tubulin acetylation.
- To explore the link between MT acetylation and disease.
Main Methods:
- Literature review of experimental data on tubulin acetylation.
- Analysis of studies on tubulin acetyltransferases and desacetylases.
- Examination of MT acetylation in stress responses and pathologies.
Main Results:
- Lys40 acetylation of α-tubulin is linked to MT stabilization and flexibility.
- Acetylation alters MT mechanical properties, preventing damage.
- Changes in MT acetylation are observed under stress and in diseases.
Conclusions:
- Tubulin acetylation is a crucial regulator of microtubule dynamics and mechanics.
- Dysregulation of tubulin acetylation impacts cell physiology and disease states.
- Further research is needed to fully elucidate the roles of tubulin acetylation.
Keywords:
HDAC6Lys40SIRT2acetylationmicrotubule-associated proteinsmicrotubule-mechanical propertiesmicrotubulespost-translational modificationstubulinαTAT1More Related Videos
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