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Intergenerational Perioperative Neurocognitive Disorder.

Ling-Sha Ju1, Timothy E Morey1, Christoph N Seubert1

  • 1Department of Anesthesiology, College of Medicine, University of Florida, P.O. Box 100254, JHMHC, 1600 SW Archer Road, Gainesville, FL 32610, USA.

Biology
|April 28, 2023
PubMed
Summary
This summary is machine-generated.

Perioperative neurocognitive disorder (PND) can affect millions. New research suggests PND in parents may impact offspring, a phenomenon termed intergenerational PND, linked to stress and inflammation.

Keywords:
heritable perioperative neurocognitive disorderperioperative neurocognitive disordersevofluranetraumatic brain injury

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Area of Science:

  • Neuroscience
  • Anesthesiology
  • Public Health

Background:

  • Perioperative neurocognitive disorder (PND) is a significant public health concern, particularly affecting older adults due to age-related increases in stress and inflammation.
  • Younger adults are generally more resilient to PND, but underlying conditions involving stress and inflammation may increase their vulnerability.
  • Emerging evidence suggests that parental PND might have lasting effects on offspring, a concept known as intergenerational PND.

Purpose of the Study:

  • To review existing literature and present experimental findings on the potential for intergenerational PND.
  • To highlight the roles of stress, inflammation, and epigenetic changes in PND development.
  • To introduce a novel animal model investigating the transmission of PND-related alterations to offspring.

Main Methods:

  • Literature review of perioperative neurocognitive disorder (PND) and related factors.
  • Experimental studies in rodent models involving surgery, traumatic brain injury, and sevoflurane exposure.
  • Assessment of stress response systems, inflammation markers, and behavioral changes in exposed adult rats and their offspring.

Main Results:

  • Surgery, TBI, and sevoflurane exposure in young adult male rats induced persistent dysregulation of stress response and inflammation.
  • These alterations were observed in the offspring of exposed rats, even without direct exposure to trauma or anesthesia.
  • This provides an animal model supporting the concept of intergenerational PND.

Conclusions:

  • Parental exposure to anesthesia/surgery may induce lasting neurocognitive and physiological changes transmissible to offspring.
  • Stress, inflammation, and epigenetic mechanisms are key factors in PND and its potential intergenerational transmission.
  • Intergenerational PND represents a potentially significant, previously unrecognized population affected by parental perioperative events.