Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Uterine Tubes01:16

Uterine Tubes

802
The uterine or fallopian tubes function as the conduit through which oocytes travel from the ovaries to the uterus. Each fallopian tube measures approximately 10 to 13 cm long and is anatomically divided into the infundibulum, ampulla, isthmus, and interstitial part (or intramural segment). The infundibulum is characterized by its funnel shape and features extensions called fimbriae which reach towards the peritoneal cavity. These fimbriae play a critical role during ovulation as they extend...
802
Ovarian Cycle01:27

Ovarian Cycle

1.5K
The menstrual cycle includes a critical component known as the ovarian cycle, which undergoes two main phases each month—the follicular phase and the luteal phase. The follicular phase is variable and averaging around 14 days. Ovulation, triggered by a surge in luteinizing hormone (LH), marks the transition between the two phases. The second phase, the luteal phase, is relatively consistent, lasting approximately 14 days, and is marked by the activity of the corpus luteum. While a cycle...
1.5K
Teratogenicity01:07

Teratogenicity

2.6K
The ability of a drug to produce structural deformations and functional abnormalities in the developing embryo or the fetus is called teratogenicity, and the drug producing this effect is known as a teratogen. Teratogenic effects include stillbirth, miscarriage, intrauterine growth restriction, and neurocognitive delay. A teratogen may affect the embryo at different stages of development, which is important in determining the type and extent of the damage. During blastocyst formation, the early...
2.6K
Hormonal Regulation of the Menstrual Cycle01:22

Hormonal Regulation of the Menstrual Cycle

532
The ovarian cycle regulates endometrial changes throughout a single menstrual cycle via the coordinated action of gonadotrophin-releasing hormone (GnRH) and gonadotrophins.
At puberty, GnRH begins a pulsatile release pattern, which triggers the anterior pituitary gland to secrete follicle-stimulating hormone (FSH) and luteinizing hormone (LH). The frequency and amplitude of GnRH pulses vary across the menstrual cycle, with faster pulses favoring LH release and slower pulses favoring FSH...
532
Transcription01:17

Transcription

23.6K
Transcription is the synthesis of RNA from a DNA sequence by RNA polymerase. It is the first step in producing a protein from a gene sequence. Additionally, many other proteins and regulatory sequences are involved in correctly synthesizing messenger RNA (mRNA). Transcriptional regulation is responsible for the differentiation of different types of cells and often for the proper cellular response to environmental signals.
Transcription Can Produce Different Kinds of RNA Molecules
In eukaryotes,...
23.6K
Uterus and Cervix01:18

Uterus and Cervix

1.6K
The uterus, commonly called the womb, is a vital reproductive organ in females designed to provide a nurturing environment for the implantation and growth of an embryo. It is shaped like a hollow pear and positioned between the urinary bladder and the rectum. The uterus's structure allows it to support and protect a developing fetus throughout pregnancy.
The uterus is securely anchored within the pelvic cavity by paired broad ligaments on either side. It is further stabilized by three pairs...
1.6K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Risk of Intra-Amniotic Infection After Cervical Ripening Balloon for Prelabor Rupture of Membranes: A Systematic Review and Meta-analysis.

Obstetrics and gynecology·2026
Same author

Successful hysteroscopic myomectomy of a submucosal leiomyoma in an adolescent female: a case report.

International journal of surgery case reports·2026
Same author

Uterine fibroids and hypertensive disorders of pregnancy: Persistence of risk regardless of myomectomy or fibroid location.

Pregnancy hypertension·2026
Same author

Flowing differently: exploratory characterization of menstrual effluent compared with peripheral blood.

F&S science·2026
Same author

Improved Cardiometabolic Health with Uterine-Preserving Fibroid Treatment Compared to Hysterectomy.

Journal of clinical medicine·2026
Same author

Assessing the impact of racial and ethnic disparities on 30-day emergency department visits after hysterectomy: A state-based retrospective cohort study.

International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics·2026

Related Experiment Video

Updated: Aug 1, 2025

Methods for Studying Uterine Contributions to Pregnancy Establishment in an Ovariectomized Mouse Model
06:49

Methods for Studying Uterine Contributions to Pregnancy Establishment in an Ovariectomized Mouse Model

Published on: April 7, 2023

1.7K

Uterine Transcriptome: Understanding Physiology and Disease Processes.

Gregory W Kirschen1, Kamran Hessami2, Abdelrahman AlAshqar3

  • 1Department of Gynecology & Obstetrics, Johns Hopkins University, Baltimore, MD 21287, USA.

Biology
|April 28, 2023
PubMed
Summary

Transcriptomics reveals dynamic endometrial mRNA changes during the menstrual cycle and in gynecological conditions. This molecular insight aids understanding and personalized therapies for reproductive health.

Keywords:
RNA sequencingendometriosisfibroidsleiomyomasmRNAmicroRNAtranscriptomics

More Related Videos

Establishing 3D Endometrial Organoids from the Mouse Uterus
06:24

Establishing 3D Endometrial Organoids from the Mouse Uterus

Published on: January 6, 2023

6.4K
Generation and Characterization of Rat Uterus Organoids from Rat Endometrial Epithelial Stem Cells
05:12

Generation and Characterization of Rat Uterus Organoids from Rat Endometrial Epithelial Stem Cells

Published on: August 2, 2024

503

Related Experiment Videos

Last Updated: Aug 1, 2025

Methods for Studying Uterine Contributions to Pregnancy Establishment in an Ovariectomized Mouse Model
06:49

Methods for Studying Uterine Contributions to Pregnancy Establishment in an Ovariectomized Mouse Model

Published on: April 7, 2023

1.7K
Establishing 3D Endometrial Organoids from the Mouse Uterus
06:24

Establishing 3D Endometrial Organoids from the Mouse Uterus

Published on: January 6, 2023

6.4K
Generation and Characterization of Rat Uterus Organoids from Rat Endometrial Epithelial Stem Cells
05:12

Generation and Characterization of Rat Uterus Organoids from Rat Endometrial Epithelial Stem Cells

Published on: August 2, 2024

503

Area of Science:

  • Reproductive Biology
  • Molecular Medicine
  • Genomics

Background:

  • Transcriptomics offers precise molecular analysis of reproductive physiology.
  • Endometrial mRNA levels change throughout the menstrual cycle, reflecting cellular and functional shifts.
  • RNA sequencing aids understanding of gynecological conditions like endometriosis, leiomyomas, and adenomyosis.

Purpose of the Study:

  • To provide an overview of recent advances in transcriptome analysis of the endometrium.
  • To highlight the role of transcriptomics in understanding normal and pathological reproductive processes.
  • To explore the potential for targeted therapies in benign gynecological conditions.

Main Methods:

  • Utilizing transcriptomic approaches, including RNA sequencing.
  • Analyzing endometrial mRNA transcript levels.
  • Profiling transcriptomes in both normal and pathological gynecological conditions.

Main Results:

  • Endometrial mRNA transcript levels exhibit fluctuations during the normal menstrual cycle.
  • These fluctuations indicate changes in inflammatory cell populations and endometrial receptivity/remodeling.
  • Transcriptome profiles offer molecular insights into pathological gynecological conditions.

Conclusions:

  • Transcriptomics enhances understanding of fundamental reproductive physiology.
  • Molecular insights into the endometrium can inform personalized therapies for gynecological disorders.
  • Further research in transcriptome analysis holds promise for improved reproductive health management.