Oxidative Stress and Inflammation in B-Cell Lymphomas
Mário Sousa-Pimenta1,2, Maria Manuela Estevinho3,4, Miguel Sousa Dias5,6
1Department of Onco-Hematology, Portuguese Institute of Oncology of Porto (IPO-Porto), 4200-072 Porto, Portugal.
Antioxidants (Basel, Switzerland)
|April 28, 2023
Summary
Reactive oxygen species (ROSs) impact lymphoma development by altering cellular signaling and the tumor microenvironment. Understanding ROS and inflammation
Area of Science:
- Oncology
- Cell Biology
- Immunology
Background:
- Lymphoid neoplasms develop through accumulated genomic alterations, influenced by inflammation and oxidative stress.
- Reactive oxygen species (ROSs), metabolic by-products, regulate cell signaling, fate, and immune functions.
- Imbalances in oxidative stress disrupt cellular processes, contributing to disease development.
Purpose of the Study:
- To review the role of reactive oxygen species (ROSs) in lymphomagenesis.
- To examine ROS regulation of microenvironmental factors in B-cell lymphomas.
- To analyze the impact of ROS on therapeutic responses in non-Hodgkin lymphomas.
Main Methods:
- This study is a narrative review, synthesizing existing research.
- Literature search focused on reactive oxygen species, inflammation, and lymphomagenesis.
- Analysis included studies on B-cell lymphomas and therapeutic implications.
Main Results:
- ROSs significantly influence lymphomagenesis by modulating signaling pathways and the tumor microenvironment.
- Dysregulated oxidative stress and inflammation are implicated in the development of lymphoid neoplasms.
- ROS levels can affect treatment efficacy in B-cell-derived non-Hodgkin lymphomas.
Conclusions:
- Reactive oxygen species play a critical role in the development and progression of lymphomas.
- Targeting ROS and inflammation pathways may offer novel therapeutic strategies for lymphomas.
- Further investigation into ROS involvement is crucial for understanding lymphoma mechanisms and developing new treatments.
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