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Redox Signaling in Chronic Kidney Disease-Associated Cachexia
Ana Cristina Simões E Silva1, Eduardo A Oliveira1, Wai W Cheung2
1Department of Pediatrics, Division of Pediatric Nephrology, Faculty of Medicine, Federal University of Minas Gerais (UFMG), Belo Horizonte 30130-100, MG, Brazil.
Antioxidants (Basel, Switzerland)
|April 28, 2023
Summary
Chronic kidney disease (CKD) causes muscle wasting due to redox signaling changes. Antioxidant and anti-inflammatory therapies show promise for treating this condition by restoring redox balance.
Area of Science:
- Nephrology
- Biochemistry
- Physiology
Background:
- Chronic kidney disease (CKD) is linked to cachexia and muscle wasting.
- Redox signaling alterations are implicated in the pathophysiology of CKD-associated muscle wasting.
- Oxidative stress is exacerbated in CKD by uremic toxins, inflammation, and metabolic changes.
Purpose of the Study:
- To review the redox pathophysiology of CKD-associated cachexia and muscle wasting.
- To discuss potential therapeutic strategies targeting redox homeostasis.
- To explore the role of antioxidant and anti-inflammatory molecules.
Main Methods:
- Literature review of studies on redox signaling in CKD-associated cachexia.
- Analysis of experimental models of kidney disease and human CKD patient data.
- Examination of therapeutic approaches including nutritional, physical, and pharmacological interventions.
Main Results:
- Oxidative stress is a significant contributor to muscle wasting in CKD.
- Antioxidant therapies have demonstrated efficacy in ameliorating CKD and its complications in experimental models.
- Nutritional, physical, and anti-inflammatory interventions show potential benefits.
Conclusions:
- Redox homeostasis disruption is central to CKD-associated cachexia.
- Targeting oxidative stress with antioxidant therapies presents a promising avenue for treatment.
- Further research is needed to develop effective therapeutic strategies for CKD-associated cachexia.
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