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Updated: Aug 1, 2025
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Assessment of Vascular Tone Responsiveness using Isolated Mesenteric Arteries with a Focus on Modulation by Perivascular Adipose Tissues
Published on: June 3, 2019
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Aging of the Arterial System.
Roberto Castelli1, Antonio Gidaro2, Gavino Casu3
1Department of Medicine, Surgery and Pharmacy, University of Sassari, 07100 Sassari, Italy.
International Journal of Molecular Sciences
|April 28, 2023
Summary
Vascular aging leads to arterial stiffness, a risk factor for cardiovascular disease. Managing conditions like hypertension and diabetes can improve arterial elasticity.
Area of Science:
- Cardiovascular Science
- Gerontology
- Nephrology
Background:
- Vascular aging involves significant structural changes in the arterial wall.
- Arterial hypertension, diabetes mellitus, and chronic kidney disease are primary drivers of reduced vascular elasticity and compliance.
- Arterial stiffness is a critical indicator of arterial wall elasticity, measurable non-invasively.
Purpose of the Study:
- To highlight the significance of arterial stiffness as an early marker of cardiovascular disease.
- To emphasize the importance of early assessment of arterial stiffness.
- To discuss the management of arterial stiffness through risk factor treatment.
Main Methods:
- Non-invasive evaluation of arterial elasticity.
- Assessment of pulse wave velocity as a measure of arterial stiffness.
Main Results:
- Alterations in arterial stiffness can precede clinical cardiovascular disease manifestations.
- No specific drug targets arterial stiffness directly.
- Treatment of associated risk factors can enhance arterial wall elasticity.
Conclusions:
- Early detection of arterial stiffness is crucial for cardiovascular risk assessment.
- Managing hypertension, diabetes, and chronic kidney disease is key to improving vascular health.
- Non-invasive methods like pulse wave velocity facilitate the assessment of arterial stiffness.
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