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The Pathogenesis of Diabetes
Huiqin Guo1, Haili Wu2, Zhuoyu Li1
1Institute of Biotechnology, The Key Laboratory of Chemical Biology and Molecular Engineering of Ministry of Education, Shanxi University, Taiyuan 030006, China.
International Journal of Molecular Sciences
|April 28, 2023
Summary
This review covers the global impact of diabetes, a common metabolic disorder. It explores glucose homeostasis, insulin resistance, and the role of long-chain non-coding RNA (lncRNA) in diabetes development.
Area of Science:
- Endocrinology and Metabolism
- Molecular Biology
- Genetics
Background:
- Diabetes mellitus is a prevalent metabolic disorder with significant global health implications.
- Type 2 diabetes accounts for 90% of cases, characterized by hyperglycemia and declining pancreatic cell function.
- Understanding molecular pathways is crucial for advancing diabetes clinical care.
Purpose of the Study:
- To review the current global landscape of diabetes.
- To elucidate the mechanisms of glucose homeostasis and insulin resistance.
- To examine the association of long-chain non-coding RNA (lncRNA) with diabetes.
Main Methods:
- Literature review of current research on diabetes.
- Analysis of molecular mechanisms underlying glucose metabolism.
- Investigation into the role of lncRNAs in diabetic pathophysiology.
Main Results:
- Diabetes poses a severe global health challenge, particularly type 2 diabetes.
- Dysregulation of glucose homeostasis and insulin resistance are key pathological features.
- lncRNAs are increasingly recognized as critical players in diabetes development and progression.
Conclusions:
- A comprehensive understanding of diabetes pathophysiology, including lncRNA involvement, is essential.
- Further research into molecular mechanisms can inform novel therapeutic strategies.
- Addressing the global burden of diabetes requires integrated approaches in clinical care and research.
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