Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Bone Remodeling

Bone Remodeling

Bone remodeling is a continuous and balanced process of bone resorption by osteoclasts and bone formation by osteoblasts. In adults, it helps maintain bone mass and calcium homeostasis. While mechanical stress can stimulate turnover as part of the normal maintenance and reparative process, several hormones also regulate bone remodeling.

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Atomic-Scale Full-Size Engineering of Platinum Nanozymes Enables High-Efficiency Catalytic Therapy.

ACS nano·2026

Same author

Multiplexed Peptide-Based Fluorescent Probe Platform for Analysis of HER2-Positive Exosomal Membrane Proteins.

Analytical chemistry·2026

Same author

The Potential Role of Tumor Microorganisms in Remodeling Tumor Biomechanical Signals and Application Strategies in Tumor Therapy.

Microorganisms·2026

Same author

Magnetic Graphene for High-Performance Isolation of Bone Marrow Mesenchymal Stem Cell-Derived Exosomes via Ca<sup>2+</sup>-Dependent Reversible Recognition.

ACS nano·2026

Same author

Integration of Bulk and Single-Cell Transcriptomics Reveals Prognostic and Immunological Roles of MTHFD2 in Clear Cell Renal Cell Carcinoma.

International journal of molecular sciences·2026

Same author

HPV testing with 16/18 genotyping for risk stratification among women with normal cytology: a multicenter prospective cohort study from China.

Journal of clinical microbiology·2026

Search research articles

Related Experiment Video

Updated: Aug 1, 2025

A Lab-On-A-Chip Platform for Stimulating Osteocyte Mechanotransduction and Analyzing Functional Outcomes of Bone Remodeling

A Lab-On-A-Chip Platform for Stimulating Osteocyte Mechanotransduction and Analyzing Functional Outcomes of Bone Remodeling

Published on: May 21, 2020

Construction of Bone Hypoxic Microenvironment Based on Bone-on-a-Chip Platforms.

Chen Li^1,2, Rong Zhao^1,2, Hui Yang²

¹Key Laboratory of Flexible Electronics of Zhejiang Province, Ningbo Institute of Northwestern Polytechnical University, Ningbo 315103, China.

International Journal of Molecular Sciences

|April 28, 2023

Summary

Bone cell function depends on oxygen levels. Microfluidic platforms enable precise control of oxygen gradients in vitro, mimicking physiological conditions for better cell research and biomedicine.

Keywords:

bone disease bone-on-a-chip platform bone marrow cell culturing hypoxic microenvironment

More Related Videos

A Human Bone Marrow 3D Model to Investigate the Dynamics and Interactions Between Resident Cells in Physiological or Tumoral Contexts

A Human Bone Marrow 3D Model to Investigate the Dynamics and Interactions Between Resident Cells in Physiological or Tumoral Contexts

Published on: December 16, 2022

3D Cell-Printed Hypoxic Cancer-on-a-Chip for Recapitulating Pathologic Progression of Solid Cancer

3D Cell-Printed Hypoxic Cancer-on-a-Chip for Recapitulating Pathologic Progression of Solid Cancer

Published on: January 5, 2021

Related Experiment Videos

Last Updated: Aug 1, 2025

A Lab-On-A-Chip Platform for Stimulating Osteocyte Mechanotransduction and Analyzing Functional Outcomes of Bone Remodeling

A Lab-On-A-Chip Platform for Stimulating Osteocyte Mechanotransduction and Analyzing Functional Outcomes of Bone Remodeling

Published on: May 21, 2020

A Human Bone Marrow 3D Model to Investigate the Dynamics and Interactions Between Resident Cells in Physiological or Tumoral Contexts

A Human Bone Marrow 3D Model to Investigate the Dynamics and Interactions Between Resident Cells in Physiological or Tumoral Contexts

Published on: December 16, 2022

3D Cell-Printed Hypoxic Cancer-on-a-Chip for Recapitulating Pathologic Progression of Solid Cancer

3D Cell-Printed Hypoxic Cancer-on-a-Chip for Recapitulating Pathologic Progression of Solid Cancer

Published on: January 5, 2021

Area of Science:

Biomedical Engineering
Cell Biology
Tissue Engineering

Background:

Bone cell physiology is critically dependent on oxygenation levels.
Standard in vitro cell cultures use normoxic conditions (141 mmHg), which exceed physiological oxygen levels in bone tissue.
Bone tissue exhibits a hypoxic microenvironment, with oxygen tension decreasing away from blood supply.

Purpose of the Study:

To review methods for creating controlled oxygen gradients in vitro.
To discuss microfluidic technologies for precise oxygen tension measurement at the microscale.
To highlight the importance of mimicking bone's hypoxic microenvironment for accurate cell studies.

Main Methods:

Review of existing literature on oxygen gradient construction.
Analysis of microfluidic platform capabilities for oxygen control and measurement.
Discussion of techniques for generating and assessing microscale oxygen tension.

Main Results:

Current in vitro methods lack precise control over oxygen levels, especially at the microscale.
Microfluidic platforms offer a solution for creating and measuring controlled oxygen gradients.
Understanding bone's hypoxic microenvironment is crucial for physiological relevance.

Conclusions:

Microfluidic technology is essential for establishing physiologically relevant hypoxic microenvironments in vitro.
This approach enhances the study of cellular responses under accurate oxygen conditions.
It provides a novel strategy for future in vitro cell-based biomedical research.