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Ginsenoside Rc from Panax Ginseng Ameliorates Palmitate-Induced UB/OC-2 Cochlear Cell Injury.

Nicholas B Gill1, Presley D Dowker-Key1, Katelin Hubbard1

  • 1Department of Nutrition, University of Tennessee Knoxville, Knoxville, TN 37996-1920, USA.

International Journal of Molecular Sciences
|April 28, 2023
PubMed
Summary

Ginsenoside Rc (G-Rc) protects against hearing loss by promoting sensory hair cell survival and differentiation. This compound alleviates inflammation and cell death, offering potential as an adjuvant therapy for sensorineural hearing loss (SNHL).

Keywords:
ER stressapoptosiscochlear hair cellsginsenghearinginflammationoxidative stressphytochemical

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Area of Science:

  • Oto-neuroscience
  • Pharmacology
  • Cell Biology

Background:

  • Sensorineural hearing loss (SNHL) affects billions, stemming from cochlear hair cell death, potentially worsened by inflammation.
  • Phytochemicals, like ginsenosides from ginseng, show promise due to anti-inflammatory, antioxidant, and anti-apoptotic properties.

Purpose of the Study:

  • To investigate the protective effects of ginsenoside Rc (G-Rc) on murine sensory hair cells against palmitate-induced injury.
  • To evaluate G-Rc's impact on cell survival, differentiation, and associated pathological pathways in hearing loss models.

Main Methods:

  • Utilized UB/OC-2 primary murine sensory hair cells exposed to palmitate-induced injury.
  • Assessed cell survival, cell cycle progression, differentiation, inflammation, endoplasmic reticulum stress, and apoptosis following G-Rc treatment.

Main Results:

  • Ginsenoside Rc (G-Rc) significantly promoted UB/OC-2 cell survival and cell cycle progression.
  • G-Rc enhanced sensory hair cell differentiation and mitigated palmitate-induced inflammation, endoplasmic reticulum stress, and apoptosis.
  • These findings highlight G-Rc's potential to counteract key mechanisms driving SNHL.

Conclusions:

  • Ginsenoside Rc (G-Rc) demonstrates significant protective effects on sensory hair cells, suggesting its therapeutic potential for SNHL.
  • Further research into the molecular mechanisms of G-Rc is warranted to develop effective adjuvant therapies for hearing loss.