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Recent Advances in Antimicrobial Peptide Hydrogels.

Aryanna Copling1, Maxwell Akantibila2, Raaha Kumaresan3

  • 1Department of Molecular & Cellular Biosciences, Rowan University, Glassboro, NJ 08028, USA.

International Journal of Molecular Sciences
|April 28, 2023
PubMed
Summary

Novel hydrogels incorporating antimicrobial peptides (AMPs) offer a promising solution to combat drug-resistant infections in medical devices. These advanced biomaterials show potential for improved wound healing and reduced device failure.

Keywords:
AMP-releasingantibiotic resistanceantimicrobial peptidebiofilmclick chemistryhydrogelphotopolymerizationself-assembling

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Area of Science:

  • Biomaterials Science
  • Infectious Disease Research
  • Drug Delivery Systems

Background:

  • Medical devices carry a risk of microbial colonization and infection, leading to device failure and increased patient morbidity.
  • The rise of drug-resistant infections due to antimicrobial overuse necessitates novel solutions.
  • Hydrogels, as versatile 3D biomaterials, can be functionalized with antimicrobial agents.

Purpose of the Study:

  • To review recent innovations (last 5 years) in antimicrobial hydrogel development.
  • To highlight the potential of photopolymerizable, self-assembling, and antimicrobial peptide (AMP)-releasing hydrogels.
  • To explore applications of these advanced hydrogels, particularly in wound healing.

Main Methods:

  • Review of recent scientific literature focusing on hydrogel synthesis and antimicrobial properties.
  • Analysis of studies incorporating inorganic molecules, metals, antibiotics, and antimicrobial peptides (AMPs) into hydrogels.
  • Examination of hydrogel systems designed for photopolymerization, self-assembly, and controlled AMP release.

Main Results:

  • Hydrogels can be effectively functionalized with various antimicrobial agents, including AMPs.
  • Photopolymerizable and self-assembling hydrogels offer tunable properties for controlled drug release.
  • AMP-tethered hydrogels demonstrate significant antimicrobial activity and potential in wound-healing applications.

Conclusions:

  • Antimicrobial peptide-releasing hydrogels represent a significant advancement in combating drug-resistant infections associated with medical devices.
  • These hydrogels offer a promising platform for developing next-generation medical devices with enhanced antimicrobial properties.
  • Further research into AMP-tethered hydrogels is crucial for their clinical translation and broader application in regenerative medicine.