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Cardiovascular Disease, Atherosclerosis and Familial Hypercholesterolemia: From Molecular Mechanisms Causing

Shifa Jebari-Benslaiman1,2, Asier Larrea-Sebal1,2,3, Asier Benito-Vicente1,2

  • 1Department of Biochemistry and Molecular Biology, Universidad del País Vasco UPV/EHU, 48080 Bilbao, Spain.

International Journal of Molecular Sciences
|April 28, 2023
PubMed

Insights

This special issue explores cardiovascular disease, atherosclerosis, and familial hypercholesterolemia. It advances understanding of molecular mechanisms and therapeutic strategies for these conditions.

Area of Science:

  • Cardiovascular Medicine
  • Molecular Biology
  • Genetics

Background:

  • Cardiovascular diseases (CVDs) remain a leading cause of mortality globally.
  • Atherosclerosis and familial hypercholesterolemia are key contributors to CVDs, driven by complex molecular pathways.
  • Current therapeutic approaches require enhancement through deeper mechanistic understanding.

Discussion:

  • This special issue focuses on the molecular mechanisms driving pathogenicity in CVD, atherosclerosis, and FH.
  • It highlights advancements in research from basic science to clinical applications.

Key Insights:

  • Elucidates novel molecular pathways involved in the development of atherosclerosis and FH.
  • Connects fundamental molecular mechanisms to clinical manifestations and disease progression.
  • Reviews current and emerging therapeutic strategies targeting these molecular pathways.

Outlook:

  • Future research directions in understanding CVD, atherosclerosis, and FH.
  • Potential for innovative therapeutic approaches based on molecular insights.
  • Integration of genetic insights into personalized treatment strategies for FH.

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