Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

A novel macrolide antibiotic, notonesomycin A.

T Sasaki, K Furihata, A Shimazu

    The Journal of Antibiotics
    |April 1, 1986
    PubMed
    Summary

    A new antifungal macrolide antibiotic, notonesomycin A, was discovered from Streptomyces fermentation. This compound shows efficacy against fungi, bacteria, and rice sheath blight disease.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Work-related psychosocial factors and metabolic syndrome onset among workers: a systematic review and meta-analysis.

    Obesity reviews : an official journal of the International Association for the Study of Obesity·2018
    Same author

    Does Internet-based cognitive behavioral therapy (iCBT) prevent major depressive episode for workers? A 12-month follow-up of a randomized controlled trial.

    Psychological medicine·2015
    Same author

    Effects on employees of controlling working hours and working schedules.

    Occupational medicine (Oxford, England)·2013
    Same author

    Detection of a single bacterial cell using a 16S ribosomal RNA-specific oligonucleotide probe designed to investigate periodontal pathogens.

    Oral microbiology and immunology·2009
    Same author

    The effect of intrathecal fentanyl added to hyperbaric bupivacaine on maternal respiratory function during Cesarean section.

    Acta anaesthesiologica Scandinavica·2006
    Same author

    Characterization of CO3Ap-collagen sponges using X-ray high-resolution microtomography.

    Biomaterials·2004

    Area of Science:

    • Microbiology
    • Natural Product Chemistry
    • Agricultural Science

    Background:

    • Streptomyces species are prolific producers of bioactive secondary metabolites.
    • Antifungal agents are crucial for controlling plant diseases and microbial infections.

    Purpose of the Study:

    • To isolate and characterize novel antifungal compounds from Streptomyces aminophilus subsp. notonesogenes.
    • To evaluate the biological activity of the isolated compounds against plant pathogens and bacteria.

    Main Methods:

    • Fermentation of Streptomyces aminophilus subsp. notonesogenes 647-AV1.
    • Isolation and structural elucidation of the main antibiotic component, notonesomycin A.
    • In vitro antimicrobial assays and greenhouse testing against rice sheath blight.

    Main Results:

    • Notonesomycin A, a new macrolide antibiotic, was identified as the primary component.
    • The molecule contains a sulfate group, malonate moiety, deoxysugars, and a trisubstituted benzene ring.
    • Notonesomycin A demonstrated in vitro activity against fungi and Gram-positive bacteria.
    • Effective control of rice sheath blight disease was observed in greenhouse trials.

    Conclusions:

    • Notonesomycin A represents a novel macrolide antibiotic with significant antifungal properties.
    • This compound holds potential for development as a therapeutic agent and agricultural fungicide.

    Related Experiment Videos