Related Experiment Video

Updated: Aug 1, 2025

Scaled-Up Preparation of an Intermediate of Upatinib, ACT051-3
08:36

Scaled-Up Preparation of an Intermediate of Upatinib, ACT051-3

Published on: April 7, 2023

1.1K

The Use of JAK/STAT Inhibitors in Chronic Inflammatory Disorders

Giuseppina Caiazzo1, Anna Caiazzo1, Maddalena Napolitano2

  • 1Department of Clinical Medicine and Surgery, University of Naples Federico II, 80138 Naples, Italy.

Journal of Clinical Medicine
|April 28, 2023
PubMed

Insights

The Janus kinase (JAK)-signal transducer and activator of transcription (STAT) pathway is crucial for immune responses and implicated in inflammatory diseases like psoriasis and IBD. This review explores its role and the use of JAK inhibitors in treatment.

Area of Science:

  • Immunology
  • Molecular Biology
  • Dermatology

Background:

  • The Janus kinase (JAK)-signal transducer and activator of transcription (STAT) pathway regulates immune and inflammatory responses.
  • This pathway is vital for cellular processes like differentiation, growth, and apoptosis.
  • Dysregulation of the JAK/STAT pathway is linked to chronic inflammatory conditions.

Purpose of the Study:

  • To review the role of the JAK/STAT signaling pathway in the pathogenesis of inflammatory diseases.
  • To focus on psoriasis, psoriatic arthritis, atopic dermatitis, and inflammatory bowel diseases, particularly ulcerative colitis.
  • To briefly summarize the clinical application of JAK inhibitors.

Main Methods:

  • Literature review of the JAK/STAT pathway's involvement in inflammatory diseases.
  • Analysis of existing research on psoriasis, psoriatic arthritis, atopic dermatitis, and inflammatory bowel diseases.
  • Summary of current therapeutic strategies involving JAK inhibitors.

Main Results:

  • The JAK/STAT pathway significantly contributes to the pathogenesis of various inflammatory conditions.
  • Specific roles in psoriasis, psoriatic arthritis, atopic dermatitis, and ulcerative colitis are detailed.
  • JAK inhibitors show promise in managing these diseases.

Conclusions:

  • The JAK/STAT pathway is a key player in immune and inflammatory disease development.
  • Understanding this pathway is crucial for developing targeted therapies.
  • JAK inhibitors represent an important therapeutic option for patients with inflammatory conditions.
Keywords:
JAK-STAT inhibitorsJAK/STAT signaling pathwayatopic dermatitisinflammatory bowel diseasesinflammatory disorderspsoriasispsoriatic arthritis

More Related Videos

Time-resolved Förster Resonance Energy Transfer Assays for Measurement of Endogenous Phosphorylated STAT Proteins in Human Cells07:12

Time-resolved Förster Resonance Energy Transfer Assays for Measurement of Endogenous Phosphorylated STAT Proteins in Human Cells

Published on: September 9, 2021

3.7K
Screening Assays to Characterize Novel Endothelial Regulators Involved in the Inflammatory Response12:50

Screening Assays to Characterize Novel Endothelial Regulators Involved in the Inflammatory Response

Published on: September 15, 2017

6.6K

Related Concept Videos

The JAK-STAT Signaling Pathway01:20

The JAK-STAT Signaling Pathway

Several cytokine receptors have tightly bound Janus kinase or JAK proteins attached at their cytosolic tail. Small signaling molecules such as cytokines, growth hormones, or prolactins bind to the cytokine receptors and initiate their dimerization. The dimerization brings the cytosolic JAKs together that trans-phosphorylate and activates each other. The activated JAKs now phosphorylate cytosolic tails of the cytokine receptors, which serve as binding sites for adaptor proteins such as  SH2...
9.0K
Drugs for Treatment of Crohn's Disease in IBD Using Biologic Agents: Anti-TNF01:24

Drugs for Treatment of Crohn's Disease in IBD Using Biologic Agents: Anti-TNF

Tumor Necrosis Factor (TNF), a proinflammatory cytokine, contributes significantly to the inflammation seen in Crohn's disease. It exists as soluble TNF and membrane-bound TNF, with actions mediated through TNF receptors (TNFR). TNFR activation leads to the release of proinflammatory cytokines, T-cell activation, collagen production, and leukocyte migration, all contributing to inflammation in Crohn's disease. Anti-TNF monoclonal antibodies, namely infliximab (Remicade), adalimumab...
185
Inflammatory Bowel Disease IV: Pharmacological Management01:29

Inflammatory Bowel Disease IV: Pharmacological Management

Upon diagnosis, managing Inflammatory Bowel Disease (IBD) involves addressing several crucial aspects. The primary goals include resting the bowel, correcting malnutrition, and providing symptomatic relief. Resting the bowel may consist of medications to reduce inflammation and promote healing. Correcting malnutrition is essential, often requiring dietary adjustments and nutritional supplements. Symptomatic relief aims to ease pain, diarrhea, and other discomforts in IBD.
Pharmacologic...
161
Drugs for Treatment of Crohn's Disease in IBD Using Immunomodulatory Agents01:29

Drugs for Treatment of Crohn's Disease in IBD Using Immunomodulatory Agents

Crohn's disease is an inflammatory bowel disorder marked by chronic inflammation of the GI tract. Various treatment strategies for Crohn's disease are employed, such as immunomodulatory agents, glucocorticoids, and biologics or anti-TNF therapy. Azathioprine (Imuran), a commonly used immunomodulatory drug for Crohn's disease, is converted in the body to mercaptopurine, which inhibits purine biosynthesis and cell proliferation. Both are utilized in severe cases of Inflammatory Bowel...
210
Drugs for Treatment of Crohn's Disease in IBD Using Glucocorticoids01:21

Drugs for Treatment of Crohn's Disease in IBD Using Glucocorticoids

Glucocorticoids, a class of anti-inflammatory drugs, are pivotal in treating moderate to severe Crohn's disease by inducing remission. They exhibit their anti-inflammatory action by inhibiting the production of inflammatory cytokines such as tumor necrosis factor (TNF)-α, interleukin (IL)-1, and chemokines like IL-8. In addition, they reduce the expression of inflammatory cell adhesion molecules and inhibit gene transcription of nitric oxide synthase, phospholipase A2, cyclooxygenase-2...
164
Inflammatory Response01:28

Inflammatory Response

An inflammatory response is a localized, nonspecific immune reaction that occurs when a tissue is injured. It is characterized by redness, swelling, heat, and pain, which are commonly called the cardinal signs and symptoms of inflammation. Inflammation can sometimes result in a loss of function.
Inflammation can be triggered by various stimuli, such as impact, abrasion, chemical irritation, infections, and extreme hot or cold temperatures. These can damage cells and connective tissue fibers,...
2.3K