Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Synthesis and Regulation of Thyroid Hormones01:20

Synthesis and Regulation of Thyroid Hormones

4.8K
Low blood levels of the thyroid hormones — triiodothyronine (T3) and thyroxine (T4) — signal the hypothalamus to release the thyrotropin-releasing hormone (TRH). TRH then reaches the pituitary gland and stimulates the release of thyroid-stimulating hormone(TSH) into the bloodstream.
Upon reaching the thyroid gland, TSH stimulates the follicular cells' active uptake of iodide ions from the blood. The ions diffuse to the apical surface of the cells and are oxidized to iodine. The...
4.8K
Hypertension III: Clinical Manifestations and Diagnostic Studies01:30

Hypertension III: Clinical Manifestations and Diagnostic Studies

36
Hypertension is asymptomatic and also referred to as the "silent killer" until it progresses to a severe stage or causes target organ disease. Patients may experience symptoms stemming from the strain on blood vessels and tissues in various organs or the heart's increased workload.Physical exams might show no abnormalities other than high blood pressure. Signs of vascular damage, when present, correspond to the organs supplied by the affected vessels, leading to target organ damage. For...
36
Myocarditis II: Clinical Features and Diagnostic Tests01:27

Myocarditis II: Clinical Features and Diagnostic Tests

14
Myocarditis is an inflammation of the heart muscle. The symptoms vary widely, encompassing asymptomatic presentations to severe, acute manifestations.Clinical PresentationAsymptomatic cases: In some instances, myocarditis may be asymptomatic, with the infection resolving without intervention. These cases often go undetected unless discovered incidentally through diagnostic imaging or tests conducted for other reasons.General Early Symptoms: Early symptoms of myocarditis are non-specific and can...
14
Major Hormones and Their Functions01:27

Major Hormones and Their Functions

565
Hormones, the biochemical messengers produced by endocrine glands, are pivotal in regulating bodily functions and maintaining homeostasis. Each hormone's balance is crucial; imbalances can lead to significant physiological disruptions. Major hormones include oxytocin, cortisol, epinephrine, estrogen, testosterone, thyroxine, growth hormone, insulin, and glucagon.
Oxytocin, produced in the hypothalamus and released by the pituitary gland, plays a role in social bonding, childbirth, and...
565
The Thyroid Gland01:23

The Thyroid Gland

4.1K
The thyroid gland is a small, butterfly-shaped gland located in the neck and covers the anterior surface of the trachea. The gland has two lateral lobes connected by a thin tissue mass called the isthmus. Internally, each lobe comprises many small spherical structures known as thyroid follicles, surrounded by a network of blood vessels.
The follicles have a central cavity lined by simple cuboidal to squamous epithelial cells called follicular cells. These cells produce the glycoprotein...
4.1K
Acute Pancreatitis II: Clinical Manifestations and Management01:30

Acute Pancreatitis II: Clinical Manifestations and Management

161
Acute pancreatitis presents a complex medical emergency characterized by rapid onset inflammation of the pancreas, demanding timely diagnosis and management to prevent complications. The condition primarily manifests through severe upper abdominal pain that often radiates to the back. This pain intensifies following the consumption of fatty foods. Accompanying symptoms such as nausea, vomiting, abdominal distention, fever, dyspnea, cyanosis, and jaundice can vary in intensity but significantly...
161

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

A double endocrine-disrupting effect of PFAS on intra- and extra-thyroid targets: inhibition of iodide uptake and interference with MCT8-mediated T3 transport in vitro.

Environmental pollution (Barking, Essex : 1987)·2026
Same author

Obesity-related thyroid reflections: from weight gain to weight loss.

European thyroid journal·2026
Same author

Six- and Twelve-Month Changes in Body Composition and 24-h Energy Expenditure After a Very Low-Calorie Ketogenic Diet.

Obesity (Silver Spring, Md.)·2026
Same author

Modulation of chemokine secretion and oxidative stress <i>in vitro</i> in thyroid cells after exposure to thiocyanate, nitrate, or perchlorate.

Frontiers in endocrinology·2026
Same author

Recurrence risk of differentiated thyroid cancer treated with total or hemithyroidectomy: systematic review and meta-analysis.

European thyroid journal·2026
Same author

Site-specific fracture risk in chronic hypoparathyroidism: systematic review and meta-analysis.

Reviews in endocrine & metabolic disorders·2026

Related Experiment Video

Updated: Aug 1, 2025

Generation of a Mouse Spontaneous Autoimmune Thyroiditis Model
04:39

Generation of a Mouse Spontaneous Autoimmune Thyroiditis Model

Published on: March 17, 2023

1.7K

Unexplained Hyperthyrotropinemia: A Biochemical and Clinical Challenge.

Laura Croce1,2, Spyridon Chytiris2, Francesca Coperchini2

  • 1Department of Internal Medicine and Therapeutics, University of Pavia, 27100 Pavia, Italy.

Journal of Clinical Medicine
|April 28, 2023
PubMed
Summary

Unexplained hyperthyrotropinemia (UH) is challenging. This study found no evidence of lab interference in UH patients, suggesting similar management to chronic autoimmune thyroiditis (CAT) until further evidence emerges.

Keywords:
laboratory interferencemacro-TSHsubclinical hypothyroidismunexplained hyperthyrotropinemia

More Related Videos

Author Spotlight: In Vivo Assessment of Thyroid Hormone Disruption Using the THAI Mouse Model
04:14

Author Spotlight: In Vivo Assessment of Thyroid Hormone Disruption Using the THAI Mouse Model

Published on: October 6, 2023

904
An Orthotopic Mouse Model of Anaplastic Thyroid Carcinoma
07:01

An Orthotopic Mouse Model of Anaplastic Thyroid Carcinoma

Published on: April 17, 2013

21.2K

Related Experiment Videos

Last Updated: Aug 1, 2025

Generation of a Mouse Spontaneous Autoimmune Thyroiditis Model
04:39

Generation of a Mouse Spontaneous Autoimmune Thyroiditis Model

Published on: March 17, 2023

1.7K
Author Spotlight: In Vivo Assessment of Thyroid Hormone Disruption Using the THAI Mouse Model
04:14

Author Spotlight: In Vivo Assessment of Thyroid Hormone Disruption Using the THAI Mouse Model

Published on: October 6, 2023

904
An Orthotopic Mouse Model of Anaplastic Thyroid Carcinoma
07:01

An Orthotopic Mouse Model of Anaplastic Thyroid Carcinoma

Published on: April 17, 2013

21.2K

Area of Science:

  • Endocrinology
  • Clinical Chemistry
  • Thyroidology

Background:

  • Unexplained hyperthyrotropinemia (UH) presents diagnostic challenges.
  • Characterizing UH is crucial for appropriate patient management.
  • Evaluating laboratory interferences is key in diagnosing UH.

Purpose of the Study:

  • To investigate potential laboratory interferences in unexplained hyperthyrotropinemia (UH).
  • To compare clinical and biochemical characteristics of UH patients with chronic autoimmune thyroiditis (CAT) and subclinical hypothyroidism.
  • To assess strategies for characterizing UH patients.

Main Methods:

  • Compared 36 UH patients with 14 CAT patients.
  • Assessed TSH normalization rates using different assay methods and over time.
  • Evaluated TSH reduction after PEG precipitation.
  • Measured free thyroxine (FT4) levels.

Main Results:

  • TSH levels and FT4 levels were similar between UH and CAT groups.
  • TSH normalization rates after repeat assays or over time did not differ significantly.
  • TSH recovery after PEG precipitation was comparable between groups.
  • No significant differences in laboratory parameters were observed between UH and CAT patients.

Conclusions:

  • Findings do not support increased laboratory interferences in UH patients.
  • Suggests managing UH patients similarly to CAT patients in the absence of other evidence.
  • Highlights the need for further research into the etiology of UH.