Immunofluorescence in the study of sclerosing retroperitonitis

Two cases of retroperitoneal fibrosis are presented. Etiopathogenetic problems connected with various drugs are discussed, among which the methysergide is of paramount importance as well as the less known drugs such as reserpine. Histologic structures were studied by immunofluorescence which gives evidence of the antigen coloring the compound with specific gamma-globulins combined with a strongly fluorescent drug (fluorescein): its positivity is clear and precise with total anti-Ig serum, as well as with anti-IgG, less weak with anti-IgA, and negative with anti-IgM. Such results advocate a tissular immunity movement and stress the theory which aims to focus retroperitoneal fibrosis within the chapter of autoimmunization diseases.