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SH3YL1 Protein Predicts Renal Outcomes in Patients with Type 2 Diabetes

Sang Youb Han1, Seung Hyun Han1, Jung Yeon Ghee2

  • 1Department of Internal Medicine, Inje University, Ilsan-Paik Hospital, Goyang 10380, Republic of Korea.

Life (Basel, Switzerland)
|April 28, 2023
PubMed

Insights

Urinary SH3YL1 protein levels can predict kidney disease progression in patients with type 2 diabetes. Higher urinary SH3YL1-to-creatinine ratio indicates increased risk of renal events.

Area of Science:

  • Nephrology
  • Diabetology
  • Biomarker Discovery

Background:

  • Oxidative stress from NADPH oxidase (NOX), particularly NOX4, drives kidney disease progression.
  • SH3 domain-containing YSC84-like 1 (SH3YL1) has emerged as a regulator of NOX4.

Purpose of the Study:

  • To investigate the potential of SH3YL1 protein as a predictor of 3-year renal outcomes in type 2 diabetes patients.
  • To assess the relationship between urinary SH3YL1 levels and markers of kidney function and damage.

Main Methods:

  • 131 type 2 diabetes patients were enrolled.
  • Renal events defined as a 15% eGFR decline, renal replacement therapy initiation, or death over 3 years.
  • Urinary SH3YL1-to-creatinine ratio (USCR) and plasma SH3YL1 levels were measured and correlated with eGFR and UACR.

Main Results:

  • USCR levels differed across CKD stages and albuminuria groups.
  • USCR negatively correlated with eGFR and positively with UACR; plasma SH3YL1 correlated with UACR.
  • Highest USCR tertile associated with significantly lower renal event-free survival and increased renal event incidence (aHR 4.636).

Conclusions:

  • SH3YL1 protein, particularly its urinary form, shows promise as a novel diagnostic biomarker for predicting renal outcomes in type 2 diabetes.
  • Elevated USCR is linked to poorer kidney function and increased risk of renal events, highlighting its clinical utility.
Keywords:
NOX4SH3YL1biomarkerdiabeteskidney

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